Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a
requisite role in the maintenance of immunological homeostasis and prevention of …

Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

Inborn errors of human interferon gamma (IFN-γ) immunity underlie mycobacterial disease.
We report a patient with mycobacterial disease due to inherited deficiency of the …

The HLH-2004 criteria are used to diagnose hemophagocytic lymphohistiocytosis (HLH), yet
concern exists for their misapplication, resulting in suboptimal treatment of some patients …

We study a patient with the human papilloma virus (HPV)-2-driven" tree-man" phenotype
and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2 …

Mice with a loss-of-function mutation in the LAT adaptor (LatY136F) develop an autoimmune
and type 2 inflammatory disorder called defective LAT signalosome pathology (DLSP). We …

Primary immunodeficiencies (PIDs) provide researchers with unique models to understand
in vivo immune responses in general and immunity to infections in particular. In humans …

B cells develop from hematopoietic stem cells in the bone marrow. Once generated, they
serve multiple roles in immune regulation and host defense. However, their most important …

A growing number of monogenic immune-mediated diseases have been related to genes
involved in pathways of actin cytoskeleton remodeling. Increasing evidences associate …

Disclosures: J. Raedler reported grants from Foerderprogramm fuer Forschung und Lehre
(FöFoLe), Medical Faculty, LMU Munich, Germany outside the submitted work. A. Fasth …