Technologies for imaging neural activity in large volumes

N Ji, J Freeman, SL Smith - Nature neuroscience, 2016 - nature.com
Neural circuitry has evolved to form distributed networks that act dynamically across large
volumes. Conventional microscopy collects data from individual planes and cannot sample …

Speed scaling in multiphoton fluorescence microscopy

J Wu, N Ji, KK Tsia - Nature Photonics, 2021 - nature.com
After over 30 years of advances, multiphoton microscopy (MPM) is now instrumental in a
wide range of in vivo biological imaging applications. However, it has, until recently …

Generation of stable heading representations in diverse visual scenes

SS Kim, AM Hermundstad, S Romani, LF Abbott… - Nature, 2019 - nature.com
Many animals rely on an internal heading representation when navigating in varied
environments,,,,,,,,–. How this representation is linked to the sensory cues that define …

A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging

P Rupprecht, S Carta, A Hoffmann, M Echizen… - Nature …, 2021 - nature.com
Inference of action potentials ('spikes') from neuronal calcium signals is complicated by the
scarcity of simultaneous measurements of action potentials and calcium signals ('ground …

Scattering compensation by focus scanning holographic aberration probing (F-SHARP)

IN Papadopoulos, JS Jouhanneau, JFA Poulet… - Nature …, 2017 - nature.com
A long-standing goal in biomedical imaging, the control of light inside turbid media, requires
knowledge of how the phase and amplitude of an illuminating wavefront are transformed as …

High fat diet induces microbiota-dependent silencing of enteroendocrine cells

L Ye, O Mueller, J Bagwell, M Bagnat, RA Liddle… - Elife, 2019 - elifesciences.org
Enteroendocrine cells (EECs) are specialized sensory cells in the intestinal epithelium that
sense and transduce nutrient information. Consumption of dietary fat contributes to …

On-chip fluorescence microscopy with a random microlens diffuser

G Kuo, F Linda Liu, I Grossrubatscher, R Ng… - Optics express, 2020 - opg.optica.org
We present an on-chip, widefield fluorescence microscope, which consists of a diffuser
placed a few millimeters away from a traditional image sensor. The diffuser replaces the …

Axial de-scanning using remote focusing in the detection arm of light-sheet microscopy

H Dibaji, A Kazemi Nasaban Shotorban… - Nature …, 2024 - nature.com
Rapid, high-resolution volumetric imaging without moving heavy objectives or disturbing
delicate samples remains challenging. Pupil-matched remote focusing offers a promising …

Network properties revealed during multi-scale calcium imaging of seizure activity in zebrafish

J Liu, SC Baraban - eneuro, 2019 - eneuro.org
Seizures are characterized by hypersynchronization of neuronal networks. Understanding
these networks could provide a critical window for therapeutic control of recurrent seizure …

A guide to emerging technologies for large-scale and whole-brain optical imaging of neuronal activity

S Weisenburger, A Vaziri - Annual review of neuroscience, 2018 - annualreviews.org
The mammalian brain is a densely interconnected network that consists of millions to billions
of neurons. Decoding how information is represented and processed by this neural circuitry …