Evolutionary medicine is a new field whose goal is to incorporate an evolutionary
perspective into medical education, research, and practice. Evolutionary biologists and …

Ca2+ has been largely recognized as an essential messenger in all eukaryotes, from
mammals to parasites. The disruption of Ca2+ homeostasis in any cell usually drives to …

The invasion of erythrocytes by Plasmodium merozoites requires specific interactions
between host receptors and parasite ligands. Parasite proteins that bind erythrocyte …

The host hormone melatonin increases cytoplasmic Ca2+ concentration and synchronizes
Plasmodium cell cycle (Hotta, CT, ML Gazarini, FH Beraldo, FP Varotti, C. Lopes, RP …

IP 3-dependent Ca 2+ signaling controls a myriad of cellular processes in higher eukaryotes
and similar signaling pathways are evolutionarily conserved in Plasmodium, the intracellular …

Discovering the mechanisms by which cell signaling controls the cell cycle of the human
malaria parasite Plasmodium falciparum is fundamental to designing more effective …

Indole compounds are involved in a range of functions in many organisms. In the human
malaria parasite Plasmodium falciparum, melatonin and other tryptophan derivatives are …

Egress of P lasmodium falciparum merozoites from host erythrocytes is a critical step in
multiplication of blood‐stage parasites. A cascade of proteolytic events plays a major role in …

Recent studies of Plasmodium falciparum isolated directly from infected patients indicate
that alternative parasite biological states occur in the natural host that are not observed with …

Parasites have evolved various mechanisms to favor infection of their hosts and enhance
the success of the infection. In this respect, time-of-day effects were found during the course …