Experimental and computational methods pertaining to drug solubility

A Jouyban, MAA Fakhree - Toxicity and drug testing, 2012 - books.google.com
Solubility of a drug is one of its important physico-chemical properties. More attention has
been paid to the aqueous solubility since water is the unique solvent of biological systems. It …

Preferential solvation of pioglitazone hydrochloride in some binary co-solvent mixtures according to the inverse Kirkwood–Buff integrals method

X Li, C Cheng, Y Cong, C Du, H Zhao - The Journal of Chemical …, 2017 - Elsevier
The preferential solvation parameters (δx 1, 3) of pioglitazone hydrochloride in four binary
solvent mixtures of {ethanol (1)+ water (2)},{N-methyl pyrrolidone (NMP)(1)+ water …

PPAR Gamma Receptor: A Novel Target to Improve Morbidity in Preterm Babies

S Victor, B Forbes, A Greenough, AD Edwards - Pharmaceuticals, 2023 - mdpi.com
Worldwide, three-quarters of a million babies are born extremely preterm (< 28 weeks
gestation) with devastating outcomes: 20% die in the newborn period, a further 35% develop …

Study of mesalazine solubility in ternary mixtures of ethanol, propylene glycol, and water at various temperatures

E Rahimpour, F Martinez, S Hemmati… - Journal of …, 2022 - Elsevier
Mesalazine is a low-permeable and low-soluble drug, which makes it a class IV drug in the
Biopharmaceutics Classification System. Hence, its solubilization can be helpful for various …

Solubility and thermodynamic parameters of a novel anti-cancer drug (DHP-5) in polyethylene glycol 400+ water mixtures

F Shakeel, MA Bhat, N Haq, A Fathi-Azarbayjani… - Journal of Molecular …, 2017 - Elsevier
Abstract Solubility of dihydropyrimidine derivative 4-(4-ethoxyphenyl)-5-(3, 4, 5
trimethoxybenzoyl)-3, 4-dihydropyrimidine-2 (1H) one (DHP-5), a novel anticancer drug …

Solubility of lamotrigine in binary and ternary mixtures of N-methyl pyrrolidone and water with polyethylene glycols 200, 400, and 600 at 298.2 K

S Soltanpour, A Jouyban - Journal of Molecular Liquids, 2013 - Elsevier
The solubility of lamotrigine in binary and ternary mixtures of N-methyl pyrrolidone and water
with polyethylene glycols 200, 400, and 600 at 25° C is determined and mathematically …

Solubility of ketoconazole in binary and ternary solvents of polyethylene glycols 200, 400 or 600 with ethanol and water at 298.2 K. Data report and analysis

S Soltanpour, V Nazemi - Journal of Solution Chemistry, 2018 - Springer
The solubilities of ketoconazole in binary and ternary mixtures of water, ethanol and
polyethylene glycols 200, 400 or 600 (185 data points) were determined at 298.2 K. Williams …

Diversity of solid forms promoted by ball milling: characterization and intrinsic dissolution studies of pioglitazone hydrochloride and fluvastatin sodium drug–drug …

M Villeda-Villegas, JC Páez-Franco, G Coyote-Dotor… - Pharmaceuticals, 2023 - mdpi.com
Coamorphous salt in a 1: 1 ratio prepared by ball milling from Fluvastatin sodium (FLV) and
Pioglitazone hydrochloride (PGZ· HCl) can be selectively formed by neat grinding (NG) …

Ball-Milling Preparation of the Drug–Drug Solid Form of Pioglitazone-Rosuvastatin at Different Molar Ratios: Characterization and Intrinsic Dissolution Rates …

MF Muñoz Tecocoatzi, JC Páez-Franco… - Pharmaceutics, 2023 - mdpi.com
Ball-milling using neat grinding (NG) or liquid-assisted grinding (LAG) by varying the polarity
of the solvents allowed access to various drug–drug solid forms of pioglitazone …

[HTML][HTML] Ball-Milling Preparation of the Drug–Drug Solid Form of Pioglitazone-Rosuvastatin at Different Molar Ratios: Characterization and Intrinsic Dissolution Rates …

MFM Tecocoatzi, JC Páez-Franco… - …, 2023 - ncbi.nlm.nih.gov
Ball-milling using neat grinding (NG) or liquid-assisted grinding (LAG) by varying the polarity
of the solvents allowed access to various drug–drug solid forms of pioglitazone …