The transparency of Caenorhabditis elegans provides a unique window to observe and
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …

In addition to several hundred microRNAs, C. elegans produces thousands of other small
RNAs targeting coding genes, pseudogenes, transposons, and other noncoding RNAs …

Transgenerational effects have wide-ranging implications for human health, biological
adaptation, and evolution; however, their mechanisms and biology remain poorly …

P granules are perinuclear condensates in C. elegans germ cells proposed to serve as hubs
for self/non-self RNA discrimination by Argonautes. We report that a mutant (meg-3 meg-4) …

Small RNAs that function in a non-cell autonomous manner are becoming increasingly
recognized as regulatory molecules with the potential to transmit information between cells …

Germ granules are biomolecular condensates that promote germ cell totipotency in animals.
In C. elegans, MEG-3 and MEG-4 function redundantly to assemble germ granules in …

piRNAs play a critical role in the regulation of transposons and other germline genes. In
Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator …

The significance of noncoding RNAs in animal biology is being increasingly recognized. The
nematode Caenorhabditis elegans has an extensive system of short RNAs that includes …

The Caenorhabditis elegans genome encodes nineteen functional Argonaute proteins that
use 22G-RNAs, 26G-RNAs, miRNAs or piRNAs to regulate target transcripts. Only one …

In animals, small noncoding RNAs that are expressed in the germline and transmitted to
progeny control gene expression to promote fertility. Germline-expressed small RNAs …