Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …

The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

Inflammasomes are important sentinels of innate immune defence, sensing pathogens and
inducing cell death in infected cells. There are several inflammasome sensors that each …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for
coronavirus disease 2019 (COVID-19), continues to cause substantial morbidity and …

Cell death provides host defense and maintains homeostasis. Zα-containing molecules are
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …

Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …

Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …

Cancers arise through the accumulation of genetic and epigenetic alterations that enable
cells to evade telomere-based proliferative barriers and achieve immortality. One such …