Over the past 25 years, the acceleration of achievements in the development of
oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the …

Nucleic acids attached to electrically conductive surfaces are very frequently used platforms
for sensing and analyte detection as well as for imaging. Synthesizing DNA on these …

The growing demand for 4′-modified nucleoside analogs in medicinal and biological
chemistry is contrasted by the challenging synthetic access to these molecules and the lack …

Biology encodes hereditary information in DNA and RNA, which are finely tuned to their
biological functions and modes of biological production. The central role of nucleic acids in …

The endo-and exo-anomeric effects are the two most recognizable stereoelectronic effects
exhibited by carbohydrates. Their presence relies on the interactions between ring …

Adjusting the protecting group strategy, from an alkyl ether to a bidentate ketal at the
carbohydrate backbone of uridine, facilitates a switchable diastereoselective α-or β …

Nucleic acid can bind to a complementary nucleic acid based on its sequence information.
Therefore, nucleic acids can be applied to technology development related to detection and …