Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …

The current standard of care for acute myocardial infarction or 'heart attack'is timely
restoration of blood flow to the ischemic region of the heart. While reperfusion is essential for …

Aging is an important risk factor for cardiovascular diseases, and aging‐related cardiac
dysfunction serves as a major determinant of morbidity and mortality in elderly populations …

Proteasomal activity is compromised in diabetic hearts that contributes to proteotoxic
stresses and cardiac dysfunction. Osteocrin (OSTN) acts as a novel exercise-responsive …

Mitochondrial dysfunction is a hallmark of cardiac pathophysiology. Defects in mitochondrial
performance disrupt contractile function, overwhelm myocytes with reactive oxygen species …

No current treatment targets cardiac proteotoxicity or can reduce mortality of heart failure
(HF) with preserved ejection fraction (HFpEF). Selective degradation of misfolded proteins …

Proteotoxicity from insufficient clearance of misfolded/damaged proteins underlies many
diseases. Carboxyl terminus of Hsc70-interacting protein (CHIP) is an important regulator of …

Background Aggrephagy is a critical compensatory mechanism for the elimination of
misfolded proteins resulting from stress and depends on the autolysosome degradation of …

Autophagy is a cellular process by which mammalian cells degrade and assist in recycling
damaged organelles and proteins. This study aimed to ascertain the role of autophagy in …

Objective Effective interventions that might limit myocardial ischemia-reperfusion (I/R) injury
are still lacking. Coenzyme Q10 (CoQ10) may exert cardioprotective actions that reduce …