[HTML][HTML] Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

A Hazrati, S Soudi, K Malekpour, M Mahmoudi… - Biomarker …, 2022 - Springer
Exosomes, ranging in size from 30 to 150 nm as identified initially via electron microscopy in
1946, are one of the extracellular vesicles (EVs) produced by many cells and have been the …

[HTML][HTML] Natural killer cell-derived extracellular vesicles: novel players in cancer immunotherapy

F Wu, M Xie, M Hun, Z She, C Li, S Luo… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells are critical components of host innate immunity and function as the
first line of defense against tumors and viral infection. There is increasing evidence that …

Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells

CH Wu, J Li, L Li, J Sun, M Fabbri… - Journal of …, 2019 - Taylor & Francis
Extracellular vesicles (EVs) are secreted membrane vesicles, which play complex
physiological and pathological functions in intercellular communication. Recently, we …

Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells

AY Jong, CH Wu, J Li, J Sun, M Fabbri… - Journal of …, 2017 - Taylor & Francis
Extracellular vesicles (EVs) have been the focus of great interest, as they appear to be
involved in numerous important cellular processes. They deliver bioactive macromolecules …

[HTML][HTML] Mechanisms of apoptosis resistance to NK cell-mediated cytotoxicity in cancer

C Sordo-Bahamonde, S Lorenzo-Herrero… - International journal of …, 2020 - mdpi.com
Natural killer (NK) cells are major contributors to immunosurveillance and control of tumor
development by inducing apoptosis of malignant cells. Among the main mechanisms …

Biological roles and potential applications of immune cell-derived extracellular vesicles

C Wen, RC Seeger, M Fabbri, L Wang… - Journal of …, 2017 - Taylor & Francis
Extracellular vesicles (EVs) deliver bioactive macromolecules (ie proteins, lipids and nucleic
acids) for intercellular communication in multicellular organisms. EVs are secreted by all cell …

[HTML][HTML] Human NK cell lytic granules and regulation of their exocytosis

K Krzewski, JE Coligan - Frontiers in immunology, 2012 - frontiersin.org
Natural killer (NK) cells form a subset of lymphocytes that play a key role in immuno-
surveillance and host defense against cancer and viral infections. They recognize stressed …

[HTML][HTML] Cyclosporine use in epidermal necrolysis is associated with an important mortality reduction: evidence from three different approaches

C Gonzalez-Herrada, S Rodriguez-Martin… - Journal of Investigative …, 2017 - Elsevier
Several immunomodulatory agents are used in the treatment of epidermal necrolysis, but
evidence of their efficacy is limited. The Autonomous Community of Madrid has two …

Blocking the CCL2–CCR2 axis using CCL2-neutralizing antibody is an effective therapy for hepatocellular cancer in a mouse model

KY Teng, J Han, X Zhang, SH Hsu, S He… - Molecular cancer …, 2017 - AACR
Hepatocellular carcinoma, a deadly disease, commonly arises in the setting of chronic
inflammation. CC motif chemokine ligand 2 (CCL2/MCP1), a chemokine that recruits CCR2 …

Natural killer cell–mediated inflammation resolution is disabled in severe asthma

MG Duvall, C Barnig, M Cernadas, I Ricklefs… - Science …, 2017 - science.org
Severe asthma is typically characterized by chronic airway inflammation that is refractory to
corticosteroids and associated with excess morbidity. Patients were recruited into the …