The role of histone modifications: from neurodevelopment to neurodiseases
J Park, K Lee, K Kim, SJ Yi - Signal transduction and targeted therapy, 2022 - nature.com
Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …
Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease
Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …
A new Bayesian factor analysis method improves detection of genes and biological processes affected by perturbations in single-cell CRISPR screening
Clustered regularly interspaced short palindromic repeats (CRISPR) screening coupled with
single-cell RNA sequencing has emerged as a powerful tool to characterize the effects of …
single-cell RNA sequencing has emerged as a powerful tool to characterize the effects of …
Transcriptional linkage analysis with in vivo AAV-Perturb-seq
The ever-growing compendium of genetic variants associated with human pathologies
demands new methods to study genotype–phenotype relationships in complex tissues in a …
demands new methods to study genotype–phenotype relationships in complex tissues in a …
Genetic and epigenetic etiology underlying autism spectrum disorder
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized
by difficulties in social interaction, language development delays, repeated body …
by difficulties in social interaction, language development delays, repeated body …
SETD2: from chromatin modifier to multipronged regulator of the genome and beyond
TM Molenaar, F van Leeuwen - Cellular and Molecular Life Sciences, 2022 - Springer
Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …
appealing proteins for targeting by small molecules in disease. However, while the functions …
H3K36 trimethylation-mediated biological functions in cancer
C Xiao, T Fan, H Tian, Y Zheng, Z Zhou, S Li, C Li… - Clinical …, 2021 - Springer
Histone modification is an important form of epigenetic regulation. Thereinto, histone
methylation is a critical determination of chromatin states, participating in multiple cellular …
methylation is a critical determination of chromatin states, participating in multiple cellular …
SETD5-coordinated chromatin reprogramming regulates adaptive resistance to targeted pancreatic cancer therapy
Molecular mechanisms underlying adaptive targeted therapy resistance in pancreatic ductal
adenocarcinoma (PDAC) are poorly understood. Here, we identify SETD5 as a major driver …
adenocarcinoma (PDAC) are poorly understood. Here, we identify SETD5 as a major driver …
A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation
Human genetics have defined a new neurodevelopmental syndrome caused by loss-of-
function mutations in MYT1L, a transcription factor known for enabling fibroblast-to-neuron …
function mutations in MYT1L, a transcription factor known for enabling fibroblast-to-neuron …
Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling
Muscle fibers are syncytial postmitotic cells that can acquire exogenous nuclei from resident
muscle stem cells, called satellite cells. Myonuclei are added to muscle fibers by satellite …
muscle stem cells, called satellite cells. Myonuclei are added to muscle fibers by satellite …