Applications of neutron and X-ray scattering to the study of biologically relevant model membranes

G Pabst, N Kučerka, MP Nieh, MC Rheinstädter… - Chemistry and Physics …, 2010 - Elsevier
Scattering techniques, in particular electron, neutron and X-ray scattering have played a
major role in elucidating the static and dynamic structure of biologically relevant …

[HTML][HTML] A biological rationale for the disparate effects of omega-3 fatty acids on cardiovascular disease outcomes

SCR Sherratt, P Libby, DL Bhatt, RP Mason - … , Leukotrienes and Essential …, 2022 - Elsevier
The omega-3 fatty acids (n3-FAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA) rapidly incorporate into cell membranes where they modulate signal transduction …

[HTML][HTML] Eicosapentaenoic acid and docosahexaenoic acid have distinct membrane locations and lipid interactions as determined by X-ray diffraction

SCR Sherratt, RP Mason - Chemistry and physics of lipids, 2018 - Elsevier
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) differentially influence lipid
oxidation, signal transduction, fluidity, and cholesterol domain formation, potentially due in …

Life cycle of an electropore: field-dependent and field-independent steps in pore creation and annihilation

ZA Levine, PT Vernier - The Journal of membrane biology, 2010 - Springer
Electropermeabilization, an electric field-induced modification of the barrier functions of the
cell membrane, is widely used in laboratories and increasingly in the clinic; but the …

Cholesterol as a co‐solvent and a ligand for membrane proteins

Y Song, AK Kenworthy, CR Sanders - Protein Science, 2014 - Wiley Online Library
As of mid 2013 a Medline search on “cholesterol” yielded over 200,000 hits, reflecting the
prominence of this lipid in numerous aspects of animal cell biology and physiology under …

Tocopherol activity correlates with its location in a membrane: a new perspective on the antioxidant vitamin E

D Marquardt, JA Williams, N Kučerka… - Journal of the …, 2013 - ACS Publications
We show evidence of an antioxidant mechanism for vitamin E which correlates strongly with
its physical location in a model lipid bilayer. These data address the overlooked problem of …

[HTML][HTML] Cholesterol crystals and atherosclerotic plaque instability: therapeutic potential of Eicosapentaenoic acid

MJ Chapman, RP Mason - Pharmacology & Therapeutics, 2022 - Elsevier
Atherosclerotic plaques associated with acute coronary syndromes (ACS), ie culprit lesions,
frequently feature a ruptured fibrous cap with thrombotic complications. On imaging, these …

[HTML][HTML] EPA and DHA containing phospholipids have contrasting effects on membrane structure

SCR Sherratt, RA Juliano, C Copland, DL Bhatt… - Journal of Lipid …, 2021 - ASBMB
Abstract Omega-3 FAs EPA and DHA influence membrane fluidity, lipid rafts, and signal
transduction. A clinical trial, Reduction of Cardiovascular Events with Icosapent Ethyl …

[HTML][HTML] Effect of melatonin and cholesterol on the structure of DOPC and DPPC membranes

E Drolle, N Kučerka, MI Hoopes, Y Choi… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The cell membrane plays an important role in the molecular mechanism of amyloid toxicity
associated with Alzheimer's disease. The membrane's chemical composition and the …

Cholesterol flip-flop: insights from free energy simulation studies

S Jo, H Rui, JB Lim, JB Klauda… - The Journal of Physical …, 2010 - ACS Publications
The mechanism of lipid flip-flop motion is important for maintaining the asymmetric
distribution of lipids in a biological membrane. To explore the energetics and mechanism of …