Obstructive sleep apnea, hypertension, and cardiovascular risk: epidemiology, pathophysiology, and management

LA Salman, R Shulman, JB Cohen - Current Cardiology Reports, 2020 - Springer
Abstract Purpose of Review Given the rising prevalence of obstructive sleep apnea (OSA),
we aimed to review the epidemiologic and pathophysiologic relationship of OSA …

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's …

MA Daulatzai - Journal of neuroscience research, 2017 - Wiley Online Library
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension

RP Pedrosa, LF Drager, CC Gonzaga, MG Sousa… - …, 2011 - Am Heart Assoc
Recognition and treatment of secondary causes of hypertension among patients with
resistant hypertension may help to control blood pressure and reduce cardiovascular risk …

Obstructive sleep apnea syndrome

MR Mannarino, F Di Filippo, M Pirro - European journal of internal medicine, 2012 - Elsevier
Obstructive sleep apnea (OSA) syndrome is a common but often unrecognized disorder
caused by pharyngeal collapse during sleep and characterized by frequent awakenings …

Mechanisms of vascular damage in obstructive sleep apnea

M Kohler, JR Stradling - Nature Reviews Cardiology, 2010 - nature.com
Obstructive sleep apnea (OSA) is characterized by repetitive apnea–hypopnea cycles
during sleep, which are associated with oxygen desaturation and sleep disruption. Up to …

Evidence of neurodegeneration in obstructive sleep apnea: relationship between obstructive sleep apnea and cognitive dysfunction in the elderly

MA Daulatzai - Journal of neuroscience research, 2015 - Wiley Online Library
The incidence of dementia and obstructive sleep apnea (OSA) increases with age. Late‐
onset Alzheimer's disease (AD) is an irreversible neurodegenerative disease of the elderly …

Hypoxia, energy balance and obesity: from pathophysiological mechanisms to new treatment strategies

B Kayser, S Verges - Obesity reviews, 2013 - Wiley Online Library
High altitude exposure is often accompanied by weight loss. Postulated mechanisms are a
reduction of nutritional energy intake, a reduction of intestinal energy uptake from impaired …

Intermittent hypoxia increases arterial blood pressure in humans through a renin-angiotensin system-dependent mechanism

GE Foster, PJ Hanly, SB Ahmed, AE Beaudin… - …, 2010 - Am Heart Assoc
Intermittent hypoxia (IH) is believed to contribute to the pathogenesis of hypertension in
obstructive sleep apnea through mechanisms that include activation of the renin-angiotensin …

Chronic obstructive pulmonary disease and the risk of stroke. The Rotterdam Study

MLP Portegies, L Lahousse, GF Joos… - American journal of …, 2016 - atsjournals.org
Rationale: Worldwide, chronic obstructive pulmonary disease (COPD) and stroke are
leading causes of death. Increasing evidence suggests an association between both …

Hypertension and obstructive sleep apnea

CL Phillips, DM O'Driscoll - Nature and science of sleep, 2013 - Taylor & Francis
Obstructive sleep apnea (OSA) is increasingly being recognized as a major health burden
with strong focus on the associated cardiovascular risk. Studies from the last two decades …