Modes of brain cell death following intracerebral hemorrhage

Y Zhang, S Khan, Y Liu, R Zhang, H Li, G Wu… - Frontiers in Cellular …, 2022 - frontiersin.org
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality
and morbidity. It induces cell death that is responsible for neurological deficits postinjury …

Autophagy regulates inflammation in intracerebral hemorrhage: Enemy or friend?

K Fu, W Xu, C Lenahan, Y Mo, J Wen… - Frontiers in Cellular …, 2023 - frontiersin.org
Intracerebral hemorrhage (ICH) is the second-largest stroke subtype and has a high
mortality and disability rate. Secondary brain injury (SBI) is delayed after ICH. The main …

Autophagy‐Associated lncRNAs: Promising Targets for Neurological Disease Diagnosis and Therapy

X Xu, L Cui, W Zhong, Y Cai - Neural plasticity, 2020 - Wiley Online Library
Neurological diseases are a major threat to global public health and prosperity. The number
of patients with neurological diseases is increasing due to the population aging and …

Inhibition of PTEN ameliorates secondary hippocampal injury and cognitive deficits after intracerebral hemorrhage: involvement of AKT/FoxO3a/ATG‐mediated …

M Zhao, J Gao, C Cui, Y Zhang… - … medicine and cellular …, 2021 - Wiley Online Library
Spontaneous intracerebral hemorrhage (ICH) commonly causes secondary hippocampal
damage and delayed cognitive impairments, but the mechanisms remain elusive. Here, we …

Risk factors of haemorrhagic transformation for acute ischaemic stroke in Chinese patients receiving intravenous thrombolysis: a meta-analysis

L Wen, S Zhang, K Wan, H Zhang, X Zhang - Medicine, 2020 - journals.lww.com
Aim: To determine the risk factors related to hemorrhagic transformation in Chinese patients
with acute ischemic stroke treated with intravenous thrombolysis. Methods: Studies …

Orexin-A exerts neuroprotective effect in experimental intracerebral hemorrhage by suppressing autophagy via OXR1-mediated ERK/mTOR signaling pathway

D Zhang, Y Cui, M Zhao, X Zheng, C Li… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Orexin-A (OXA) is a polypeptide produced in the hypothalamus, which binds to
specific receptors and exerts multiple physiological effects. Autophagy plays a vital role in …

Mechanisms and therapeutic targets of mitophagy after intracerebral hemorrhage

Q Huang, X Yu, P Fu, M Wu, X Yin, Z Chen, M Zhang - Heliyon, 2024 - cell.com
Mitochondria are dynamic organelles responsible for cellular energy production. In addition
to regulating energy homeostasis, mitochondria are responsible for calcium homeostasis …

Exosomes derived from human umbilical cord mesenchymal stem cells pretreated by monosialoteterahexosyl ganglioside alleviate intracerebral hemorrhage by down …

D Yan, Y Shi, C Nan, Q Jin, Y Zhuo, H Huo… - Experimental Cell …, 2024 - Elsevier
Purpose Intracerebral hemorrhage (ICH) results in substantial morbidity, mortality, and
disability. Depleting neural cells in advanced stages of ICH poses a significant challenge to …

Secondary injury and inflammation after intracerebral haemorrhage: a systematic review and meta-analysis of molecular markers in patient brain tissue

JJM Loan, C Kirby, K Emelianova… - Journal of Neurology …, 2022 - jnnp.bmj.com
Background Inflammatory responses to intracerebral haemorrhage (ICH) are potential
therapeutic targets. We aimed to quantify molecular markers of inflammation in human brain …

Biological effects of hydrogen sulfide and its protective role in intracerebral hemorrhage

J Zhang, H Shan, L Tao, M Zhang - Journal of Molecular Neuroscience, 2020 - Springer
Intracerebral hemorrhage (ICH) has extremely high morbidity and mortality, substantially
impacting public health. Studying the pathophysiological mechanisms of ICH is a …