[HTML][HTML] Reg gene family and human diseases

YW Zhang, LS Ding, MD Lai - World journal of gastroenterology …, 2003 - ncbi.nlm.nih.gov
Regenerating gene (Reg or REG) family, within the superfamily of C-type lectin, is mainly
involved in the liver, pancreatic, gastric and intestinal cell proliferation or differentiation …

[HTML][HTML] Copy number variations in pancreatic cancer: from biological significance to clinical utility

DJA Oketch, M Giulietti, F Piva - International Journal of Molecular …, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer,
characterized by high tumor heterogeneity and a poor prognosis. Inter-and intra-tumoral …

Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse‐type gastric carcinoma‐initiating cells is inhibited by …

Y Katsuno, S Ehata, M Yashiro… - The Journal of …, 2012 - Wiley Online Library
Abstract Aldehyde dehydrogenase 1 (ALDH1) has been shown to serve as a marker for
cancer‐initiating cells (CICs), but little is known about the regulation of the CIC functions of …

Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas

KS Bishnupuri, Q Luo, N Murmu, CW Houchen… - Gastroenterology, 2006 - Elsevier
Background & Aims: Reg IV, a secreted protein and member of the Reg multigene family, is
up-regulated in malignancies of the human gastrointestinal tract, including colorectal …

Expression and localization of Reg IV in human neoplastic and non‐neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine …

N Oue, Y Mitani, PP Aung, C Sakakura… - The Journal of …, 2005 - Wiley Online Library
Regenerating islet‐derived family, member 4 (Reg IV) is a candidate marker for cancer and
inflammatory bowel disease. In the present study, immunohistochemical analysis of Reg IV …

[图书][B] Animal lectins: form, function and clinical applications

GS Gupta - 2012 - books.google.com
Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of
animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular …

The potential role of REG family proteins in inflammatory and inflammation-associated diseases of the gastrointestinal tract

C Sun, X Wang, Y Hui, H Fukui, B Wang… - International Journal of …, 2021 - mdpi.com
Regenerating gene (REG) family proteins serve as multifunctional secretory molecules with
trophic, antiapoptotic, anti-inflammatory, antimicrobial and probably immuno-regulatory …

REG4 promotes the proliferation and anti-apoptosis of cancer

HC Zheng, H Xue, CY Zhang - Frontiers in cell and developmental …, 2022 - frontiersin.org
Regenerating islet-derived 4 (REG4) gene was discovered by high-throughput sequencing
of ulcerative colitis cDNA libraries. REG4 is involved in infection and inflammation by …

Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma

YG Li, DF Ji, S Zhong, JX Zhu, S Chen… - International journal of …, 2011 - Elsevier
Proteoglycan (P1) purified from Phellinus linteus has been reported to have anti-disease
activities. The objectives of our research were to determine the anti-tumor effect and …

A kernel-based integration of genome-wide data for clinical decision support

A Daemen, O Gevaert, F Ojeda, A Debucquoy… - Genome medicine, 2009 - Springer
Background Although microarray technology allows the investigation of the transcriptomic
make-up of a tumor in one experiment, the transcriptome does not completely reflect the …