Role of glioblastoma stem cells in cancer therapeutic resistance: A perspective on antineoplastic agents from natural sources and chemical derivatives
ALV Alves, INF Gomes, AC Carloni, MN Rosa… - Stem Cell Research & …, 2021 - Springer
Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …
Glioblastoma: current status, emerging targets, and recent advances
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …
population of genetically unstable and highly infiltrative cells that are resistant to …
Metformin and cancer, an ambiguanidous relationship
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus,
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …
Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells
Metformin, a first line medication for type II diabetes, initially entered the spotlight as a
promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk …
promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk …
Targeting cancer stem cells to suppress acquired chemotherapy resistance
SJ Vidal, V Rodriguez-Bravo, M Galsky… - Oncogene, 2014 - nature.com
Acquired resistance has curtailed cancer survival since the dawn of the chemotherapy age
more than half a century ago. Although the application of stem cell (SC) concepts to cancer …
more than half a century ago. Although the application of stem cell (SC) concepts to cancer …
Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation
The imprinted, developmentally regulated H19 long noncoding RNA has been implicated in
the pathogenesis of diverse human cancers, but the underlying mechanisms have remained …
the pathogenesis of diverse human cancers, but the underlying mechanisms have remained …
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response
J Sesen, P Dahan, SJ Scotland, E Saland, VT Dang… - PloS one, 2015 - journals.plos.org
High-grade gliomas, glioblastomas (GB), are refractory to conventional treatment combining
surgery, chemotherapy, mainly temozolomide, and radiotherapy. This highlights an urgent …
surgery, chemotherapy, mainly temozolomide, and radiotherapy. This highlights an urgent …
Metabolic drivers of invasion in glioblastoma
Glioblastoma is a primary malignant brain tumor with a median survival under 2 years. The
poor prognosis glioblastoma caries is largely due to cellular invasion, which enables escape …
poor prognosis glioblastoma caries is largely due to cellular invasion, which enables escape …
Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds
Highlights•De novo anticancer drug discovery is challenging and repurposing in oncology is
a promising field.•Drug repositioning increasingly emerges as faster, cheaper and …
a promising field.•Drug repositioning increasingly emerges as faster, cheaper and …
[HTML][HTML] Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic …
M Peretti, M Angelini, N Savalli, T Florio… - … et Biophysica Acta (BBA …, 2015 - Elsevier
In recent decades, growing scientific evidence supports the role of ion channels in the
development of different cancers. Both potassium selective pores and chloride …
development of different cancers. Both potassium selective pores and chloride …