Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases
(NOS) which plays a critical role in a number of physiological and pathological processes in …

Neurodegenerative diseases are a set of diseases in which slow and progressive neuronal
loss occurs. Nitric oxide (NO) as a neurotransmitter performs key roles in the stimulation and …

The blood–CSF barrier (BCSFB) consists of a monolayer of choroid plexus epithelial (CPE)
cells that maintain CNS homeostasis by producing CSF and restricting the passage of …

Background Neuroinflammation characterized by glial activation and release of
proinflammatory mediators is considered to play a critical role in the pathogenesis of …

Increasing evidence indicates that extracellular vesicles (EVs) play an important role in the
pathogenesis of Alzheimer's disease (AD). We previously reported that the blood …

Environmental pollutants act as risk factors for Alzheimer's disease (AD), mainly affecting the
aging population. We investigated early manifestations of AD-like pathology by a mixture of …

Alzheimer's disease (AD) is one of the prevalent neurological disorders of the central
nervous system hallmarked by increased beta-amyloid (Aβ) deposition and ensuing …

Alzheimer's disease (AD) is the most common form of dementia, and neuroinflammation is
an important hallmark of the pathogenesis. Tumor necrosis factor (TNF) might be detrimental …

A novel series of hybrid molecules were designed and synthesized by fusing the
pharmacophoric features of cholinesterase inhibitor donepezil and diarylthiazole as …

Currently, mesenchymal stem cells (MSCs) based therapy has extensive attraction for
Alzheimer's disease (AD). However, low survival rate of MSCs after transplantation is a huge …