Natural and de novo designed peptides are gaining an ever-growing interest as drugs
against several diseases. Their use is however limited by the intrinsic low bioavailability and …

Disease-modifying therapies (DMT) for Alzheimer's disease (AD) are highly longed-for. In
this quest, anti-amyloid therapies take center stage supported by genetic facts that highlight …

Alzheimer's disease (AD) is characterized by the accumulation of extracellular plaques
composed by amyloid-β (Aβ) and intracellular neurofibrillary tangles of hyperphosphorylated …

The disruption of mitochondria‐associated endoplasmic reticulum (ER) membranes (MAMs)
plays a relevant role in Alzheimer's disease (AD). MAMs have been implicated in neuronal …

Alzheimer's disease (AD) is implicated in the imbalance of several proteins, including
Amyloid-β (Aβ), amyloid precursor protein (APP), and BACE1. APP overexpression …

Alzheimer's disease (AD) is a chronic neurological condition that has become a leading
cause of cognitive decline in elder individuals. Hardly any effective medication has been …

BACKGROUND: Cleistocalyx nervosum var. paniala (C. nervosum) is a plant that produces
berries that are popular as a health food in Thailand. In previous studies we have identified …

This study aims to evaluate whether mitochondrial changes occur in the early stages of
bipolar disorder (BD). Using fibroblasts derived from BD patients and matched controls, the …

Background Despite the accumulating research efforts, the current treatment of Alzheimer's
disease (AD) remains far from achieving any clinical success in modifying the underlying …

Alzheimer's disease (AD) is characterized by progressive neurodegeneration. The critical
molecular trigger is believed to be the accumulation of Aβ neurotoxic oligomers. Given the …