Joint arthroplasty had revolutionized the outcome of orthopaedic surgery. Extensive and
collaborative work of many innovator surgeons had led to the development of durable …

Intracorporally implanted materials, such as medical devices, will provoke the body to initiate
an in-flammatory reaction. This inflammatory reaction to implanted materials is known as the …

In the laboratory environment where biomaterials are synthesized and their biocompatibility
assessed, we find that endotoxin contamination is hard to avoid and must not be ignored. In …

Despite the beneficial properties and outstanding potential of hydrogels for biomedical
applications, several unmet challenges must be overcome, especially regarding to their …

Macrophages are the primary mediator of chronic inflammatory responses to implanted
biomaterials, in cases when the material is either in particulate or bulk form. Chronic …

Bacterial colonization is a secondary feature of many lung disorders associated with
elevated cytokine levels and increased leukocyte recruitment. We hypothesized that …

Inhalation of particulate matter (PM) may result in exacerbation of inflammatory airways
disease, including asthma. Results from this laboratory have shown that the coarse …

Aseptic loosening of orthopedic implants is thought to be caused primarily by osteoclast
differentiation induced by bone resorptive cytokines produced in response to phagocytosis …

In the lower airways, macrophages are important regulators of inflammation and
indispensable in their antimicrobial activities. Thus, air pollution particles, which modulate …

BACKGROUND: In vitro, endotoxin on coarse fraction particulate matter (PM2. 5-10)
accounts for the majority of the ability of PM2. 5-10 to induce cytokine responses from …