Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Disseminated tumor cells (DTCs) are known to enter a state of dormancy that is achieved via
growth arrest of DTCs and/or a form of population equilibrium state, strongly influenced by …

In contrast to nearly all other tissues, the anatomy of cell differentiation in the bone marrow
remains unknown. This is owing to a lack of strategies for examining myelopoiesis—the …

Chronic myeloid leukemia (CML) is caused by BCRABL1 in a cell with the biological
potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML …

The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from
chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of …

Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess
the capacity to differentiate into different cell lineages. Maintaining a balanced stem cell …

NF-κB is a key regulator of inflammation and cancer progression, with an important role in
leukemogenesis. Despite its therapeutic potential, targeting NF-κB using pharmacologic …

Over the years, developments in oncology led to significantly improved clinical outcome for
cancer patients. However, cancer recurrence after initial treatment response still poses a …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …

Over the past few decades, si RNA and mi RNA have attracted a great deal of attention from
researchers and clinicians. These molecules have been extensively studied from the …