Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and
functional decline associated with age together with a particular neuropathology. It was first …

Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …

Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

Neurons are particularly susceptible to energy fluctuations in response to stress.
Mitochondrial fission is highly regulated to generate ATP via oxidative phosphorylation; …

Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …

The spatiotemporal organization of neurotransmitter receptors in the postsynaptic
membrane is a fundamental determinant of synaptic transmission and thus of information …

Experience-dependent learning and memory require multiple forms of plasticity at
hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors …

Maternal immune activation (MIA) induced by lipopolysaccharides or polyinosinic:
polycytidylic acid injections can induce behavioral abnormalities in adult mouse offspring …