Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - ASPET
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

Glucagon-like peptide-1 receptor agonists for treatment of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an updated meta-analysis of randomized …

A Mantovani, G Petracca, G Beatrice, A Csermely… - Metabolites, 2021 - mdpi.com
To assess the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for
treatment of nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH), we …

Short chain fatty acids in the colon and peripheral tissues: a focus on butyrate, colon cancer, obesity and insulin resistance

SM McNabney, TM Henagan - Nutrients, 2017 - mdpi.com
Increased dietary fiber consumption has been associated with many beneficial effects,
including amelioration of obesity and insulin resistance. These effects may be due to the …

Menstrual cycle rhythmicity: metabolic patterns in healthy women

CF Draper, K Duisters, B Weger, A Chakrabarti… - Scientific reports, 2018 - nature.com
The menstrual cycle is an essential life rhythm governed by interacting levels of
progesterone, estradiol, follicular stimulating, and luteinizing hormones. To study metabolic …

Acylcarnitines—old actors auditioning for new roles in metabolic physiology

CS McCoin, TA Knotts, SH Adams - Nature Reviews Endocrinology, 2015 - nature.com
Perturbations in metabolic pathways can cause substantial increases in plasma and tissue
concentrations of long-chain acylcarnitines (LCACs). For example, the levels of LCACs and …

Novel biomarkers for prediabetes, diabetes, and associated complications

B Dorcely, K Katz, R Jagannathan… - … syndrome and obesity …, 2017 - Taylor & Francis
The number of individuals with prediabetes is expected to grow substantially and estimated
to globally affect 482 million people by 2040. Therefore, effective methods for diagnosing …

Metabolomic profiling identifies novel circulating biomarkers of mitochondrial dysfunction differentially elevated in heart failure with preserved versus reduced ejection …

WG Hunter, JP Kelly, RW McGarrah III… - Journal of the …, 2016 - Am Heart Assoc
Background Metabolic impairment is an important contributor to heart failure (HF)
pathogenesis and progression. Dysregulated metabolic pathways remain poorly …

Global analysis of plasma lipids identifies liver-derived acylcarnitines as a fuel source for brown fat thermogenesis

J Simcox, G Geoghegan, JA Maschek, CL Bensard… - Cell metabolism, 2017 - cell.com
Cold-induced thermogenesis is an energy-demanding process that protects endotherms
against a reduction in ambient temperature. Using non-targeted liquid chromatography …

Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients

H Castañé, S Iftimie, G Baiges-Gaya… - Metabolism, 2022 - Elsevier
Background Lipids are involved in the interaction between viral infection and the host
metabolic and immunological responses. Several studies comparing the lipidome of COVID …

Metabolomic analysis of obesity, metabolic syndrome, and type 2 diabetes: amino acid and acylcarnitine levels change along a spectrum of metabolic wellness

DM Libert, AS Nowacki, MR Natowicz - PeerJ, 2018 - peerj.com
Background Metabolic syndrome (MS) is a construct used to separate “healthy” from
“unhealthy” obese patients, and is a major risk factor for type 2 diabetes (T2D) and …