The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …

White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

Background: Cerebral hypoperfusion has previously been associated with mild cognitive
impairment and dementia in various cross-sectional studies, but whether hypoperfusion …

Cerebral small vessel disease (CSVD) is a very common neurological disease in older
people. It causes stroke and dementia, mood disturbance and gait problems. Since it is …

Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Recent epidemiological and clinico-pathological data indicate considerable overlap
between cerebrovascular disease (CVD) and Alzheimer's disease (AD) and suggest …

Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain
hemorrhages and is a leading cause of cognitive decline and functional loss in elderly …

The term cerebral small vessel disease (SVD) describes a range of neuroimaging,
pathological, and associated clinical features. Clinical features range from none, to discrete …

The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or vascular
smooth muscle cells, glia and neurons. The NVU controls blood–brain barrier (BBB) …