The single most common cause of the withdrawal or restriction of the use of marketed drugs
has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or …

Sudden cardiac death occurs in a broad spectrum of cardiac pathologies and is an important
cause of mortality in the general population. Genetic studies conducted during the past 20 …

1From Mayo Clinic, Rochester, Minnesota; 2Fondazione Salvatore Maugeri University of
Pavia, Pavia, Italy and New York University, New York, New York; 3University Hospital …

Background—The prevalence of genetic arrhythmogenic diseases is unknown. For the long-
QT syndrome (LQTS), figures ranging from 1: 20 000 to 1: 5000 were published, but none …

Background Mutations in potassium-channel genes KCNQ1 (LQT1 locus) and KCNH2
(LQT2 locus) and the sodium-channel gene SCN5A (LQT3 locus) are the most common …

Background—Catecholaminergic polymorphic ventricular tachycardia is a genetic
arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular …

Background—Mutations in the cardiac ryanodine receptor gene (RyR2) underlie
catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited arrhythmogenic …

The members of the Task Force on Sudden Death dedicate this paper to the memory of our
former friend and colleague, Professor Ronald WF Campbell. Ronnie spent his life working …

Background—Long-QT Syndrome (LQTS) is a cardiovascular disorder characterized by
prolongation of the QT interval on ECG and presence of syncope, seizures, and sudden …

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US base rate, has been added and will be paid by Mosby to Revenue Canada under GST …