Hypoxic modulation of HLA‐G expression through the metabolic sensor HIF‐1 in human cancer cells

M Garziera, L Scarabel, G Toffoli - Journal of immunology …, 2017 - Wiley Online Library
The human leukocyte antigen‐G (HLA‐G) is considered an immune checkpoint molecule
involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia‐inducible …

[HTML][HTML] Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2

L Yaghi, I Poras, RT Simoes, EA Donadi, J Tost… - Oncotarget, 2016 - ncbi.nlm.nih.gov
HLA-G is an immune checkpoint molecule with specific relevance in cancer immunotherapy.
It was first identified in cytotrophoblasts, protecting the fetus from maternal rejection. HLA-G …

Computational and atomistic studies applied to the understanding of the structural and behavioral features of the immune checkpoint HLA-G molecule and gene

CC Alves, T Arns, ML Oliveira, P Moreau, DA Antunes… - Human Immunology, 2023 - Elsevier
We took advantage of the increasingly evolving approaches for in silico studies concerning
protein structures, protein molecular dynamics (MD), protein-protein and protein-DNA …

Evolution of the levels of human leukocyte antigen G (HLA-G) in Beninese infant during the first year of life in a malaria endemic area: using latent class analysis

TC d'Almeida, I Sadissou, G Cottrell, R Tahar… - Malaria journal, 2016 - Springer
Background HLA-G, a non-classical HLA class I antigen, is of crucial interest during
pregnancy by inhibiting maternal immune response. Its role during infections is discussed …

HLA-G 3'UTR haplotype frequencies in highland and lowland South Native American populations

VC Jacovas, RT Michita, R Bisso-Machado, G Reales… - Human Immunology, 2022 - Elsevier
Abstract Human Leukocyte Antigen (HLA)-G participates in several biological processes,
including reproduction, vascular remodeling, immune tolerance, and hypoxia response. HLA …

[HTML][HTML] Controlled hypobaric hypoxia increases immunological tolerance by modifying HLA-G expression, a potential therapy to inflammatory diseases

M Ziliotto, RM Rodrigues, JAB Chies - Medical Hypotheses, 2020 - Elsevier
One of the most striking characteristics of human beings is the incredible capacity to adapt to
different environments. This capacity allowed humans to spread all over our planet …

Effect of extreme conditions of Antarctica on human leukocyte antigen-G in Indian expeditioners

KP Mishra, AP Yadav, YK Sharma… - Indian Journal of …, 2014 - journals.lww.com
Methods: sHLA-G ELISA was performed in the serum of summer (n= 27) and winter (n= 22)
Indian Antarctic expeditioners. The summer expeditioners were evaluated at three different …

Desvendando mecanismos genéticos de adaptação à alta altitude em populações nativas americanas dos Andes

VC Jacovas - 2019 - lume.ufrgs.br
O estudo da adaptação humana para vida em altas altitudes é um tema bastante abordado
na literatura científica mundial, tanto no que se refere às adaptações genéticas, quanto às …

[PDF][PDF] Effect of Antarctic Environment on Immune Response of Indian Expedition Members

KP Mishra, AP Yadav, L Ganju, S Chanda - 2019 - 14.139.119.23
The Antarctica presents the coldest (temperatures between–25 C and–89 C), driest
(average RH 0.03%), and windiest (chilly all-year Katabatic winds averaging 15-50 m/h) …

Étude de l'antigène du complexe majeur d'histocompatibilité HLA-G: rôle dans le phénomène de tolérance immunitaire au cours de l'infection palustre

TCDA d'Almeida - 2017 - theses.hal.science
Les femmes enceintes et les enfants sont les populations à haut risque pour le paludisme.
Chez les premières, l'infection peut entraîner une infection placentaire (IP). Les enfants nés …