Mechanisms of selective toxicity of metronidazole and other nitroimidazole drugs.

DI Edwards - Sexually Transmitted Infections, 1980 - sti.bmj.com
The selectively toxic effect of nitroimidazole drugs towards anaerobic bacteria and protozoa
depends on a number of factors. The killing action of such drugs as metronidazole requires …

[HTML][HTML] Sexually transmitted diseases treatment guidelines, 2015

KA Workowski, GA Bolan… - 2015 - cdc.gov
These guidelines for the treatment of persons who have or are at risk for sexually transmitted
diseases (STDs) were updated by CDC after consultation with a group of professionals …

[HTML][HTML] Sexually transmitted diseases treatment guidelines, 2006

KA Workowski, SM Berman… - MMWR recomm …, 2006 - cdc.gov
These guidelines for the treatment of persons who have sexually transmitted diseases
(STDs) were developed by CDC after consultation with a group of professionals …

Metronidazole: review of uses and toxicity.

FJC Roe - 1977 - cabidigitallibrary.org
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Metronidazole for Crohn's disease

B Ursing, C Kamme - The Lancet, 1975 - Elsevier
Five patients with Crohn's disease for 4 months to 12 years were treated with metronidazole.
Four of them improved after 2-4 weeks' treatment. In three of them corticosteroids and …

Inhibition of phagocytosis in vitro by obligate anaerobes

HR Ingham, D Tharagonnet, PR Sisson, JB Selkon… - The Lancet, 1977 - Elsevier
A variety of species of obligate anaerobes have been shown to interfere with the
phagocytosis and killing of Proteus mirabilis and other aerobic bacteria in vitro. Although all …

The interaction of reduced metronidazole with DNA

RC Knight, IM Skolimowski, DI Edwards - Biochemical pharmacology, 1978 - Elsevier
Electrolytic reduction of metronidazole was carried out at a controlled potential under
anaerobic conditions in the presence of calf-thymus DNA. The DNA was subsequently …

Antimicrobial activity of metronidazole in anaerobic bacteria

FP Tally, BR Goldin, N Sullivan… - Antimicrobial agents …, 1978 - Am Soc Microbiol
The antimicrobial activity of metronidazole was investigated in anaerobic bacteria by use of
time-viability studies. This antimicrobial agent has a rapid onset of bactericidal activity under …

Experimental animal models for anaerobic infections

AB Onderdonk, DL Kasper, BJ Mansheim… - Reviews of infectious …, 1979 - academic.oup.com
An experimental animal model that simulates the mixed aerobic-anaerobic microflora of
intraabdominal sepsis was used to study antimicrobial efficacy in vivo. Treatment of infected …

Metronidazole in prevention and treatment of bacteroides infections in elective colonic surgery.

AT Willis, IR Ferguson, PH Jones, KD Phillips… - Br Med J, 1977 - bmj.com
A double-blind randomised trial was carried out among 46 patients undergoing elective
colonic surgery; 27 patients received prophylactic metronidazole and 19 received placebo …