Over recent decades, the global burden of fungal disease has expanded dramatically. It is
estimated that fungal disease kills approximately 1.5 million individuals annually; however …

There is an urgent unmet need for novel antifungals. In this study, we searched for novel
antifungal activities in the Pandemic Response Box, a collection of 400 structurally diverse …

The current therapeutic challenges for treating fungal diseases demand new approaches
and new drugs. A promising strategy involves combination therapy with agents of distinct …

Acylhydrazone (AH) derivatives represent a novel category of anti-fungal medications that
exhibit potent activity against Sporothrix sp., both in vitro and in a murine model of …

The fight against resistance to antifungal drugs requires a better understanding of the
underlying cellular mechanisms. In order to gain insight into the mechanisms leading to …

Lipids play a fundamental role in fungal cell biology, being essential cell membrane
components and major targets of antifungal drugs. A deeper knowledge of lipid metabolism …

Brazilian medical mycology considerably expanded in the last decades due to the efforts of
several pioneers who started and expanded mycology during the twentieth century. In this …

Currently deployed fungicides cover a narrow range of molecular targets. With the threat of
resistance development, there is a pressing need to identify novel targets for fungicides. This …