Since the first description in 1989 of CD4‐Fc‐fusion antagonists that inhibit human immune
deficiency virus entry into T cells, Fc‐fusion proteins have been intensely investigated for …

Catharanthus roseus is a medicinal plant belonging to the family Apocynaceae which
produces terpenoid indole alkaloids (TIAs) of high medicinal importance. Indeed, a number …

Synthetic biology has advanced the design of genetic devices that can be used to reprogram
metabolic activities in mammalian cells. By functionally linking the signal transduction of …

Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

Known treatments of type 2 diabetes mellitus have limitations such as weight gain, and
hypoglycaemias. A new perspective is the use of incretin hormones and incretin enhancers …

Long-term treatment with glucagon-like peptide (GLP)-1 or its analog can improve insulin
sensitivity. However, continuous administration is required due to its short half-life. We …

Synthetic biology has significantly advanced the design of genetic devices that can
reprogram cellular activities and provide novel treatment strategies for future gene-and cell …

Glucagon-like peptide 1 (GLP-1) improves insulin resistance of adipose tissue in obese
humans. However, the mechanism of this effect is unclear. Perturbation of endoplasmic …

The application of Fc (fragment crystallizable)-based cytokines (the fusion of the constant
region of IgG to a cytokine of interest) as biotherapeutic agents to modulate inflammatory …

The goal of drug delivery is to improve the safety and therapeutic efficacy of drugs. This
review focuses on delivery platforms that are either derived from endogenous pathways …