Reinventing radiobiology in the light of FLASH radiotherapy

CL Limoli, MC Vozenin - Annual Review of Cancer Biology, 2023 - annualreviews.org
Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting
treatment modality that holds the promise of expanding the therapeutic index for nearly any …

The pro-tumorigenic host response to cancer therapies

Y Shaked - Nature Reviews Cancer, 2019 - nature.com
Resistance to cancer therapy remains a major challenge in clinical oncology. Although the
initial treatment phase is often successful, eventual resistance, characterized by tumour …

Antitumor applications of photothermal agents and photothermal synergistic therapies

C Li, Y Cheng, D Li, Q An, W Zhang, Y Zhang… - International Journal of …, 2022 - mdpi.com
As a new tumor treatment strategy, photothermal therapy (PTT) has the advantages of
accuracy, ease of administration, a high efficiency and low side effects. Photothermal …

Two-dimensional cancer theranostic nanomaterials: Synthesis, surface functionalization and applications in photothermal therapy

C Murugan, V Sharma, RK Murugan… - Journal of Controlled …, 2019 - Elsevier
In recent years, novel two-dimensional (2D) nanomaterials are of great interest for diverse
potential applications such as device fabrication, energy storage, sensing and theranostics …

Next generation of tumor-activating type I IFN enhances anti-tumor immune responses to overcome therapy resistance

X Cao, Y Liang, Z Hu, H Li, J Yang, EJ Hsu… - Nature …, 2021 - nature.com
Type I interferon is promising in treating different kinds of tumors, but has been limited by its
toxicity, lack of tumor targeting, and very short half-life. To target tumors, reduce systemic …

Radiation-induced chromosomal aberrations and immunotherapy: micronuclei, cytosolic DNA, and interferon-production pathway

M Durante, SC Formenti - Frontiers in oncology, 2018 - frontiersin.org
Radiation-induced chromosomal aberrations represent an early marker of late effects,
including cell killing and transformation. The measurement of cytogenetic damage in tissues …

Nanotechnology applications in breast cancer immunotherapy

R Wang, P Kumar, M Reda, AG Wallstrum… - Small, 2024 - Wiley Online Library
Next‐generation cancer treatments are expected not only to target cancer cells but also to
simultaneously train immune cells to combat cancer while modulating the immune …

A nanomedicine structure–activity framework for research, development, and regulation of future cancer therapies

B Youden, R Jiang, AJ Carrier, MR Servos, X Zhang - ACS nano, 2022 - ACS Publications
Despite their clinical success in drug delivery applications, the potential of theranostic
nanomedicines is hampered by mechanistic uncertainty and a lack of science-informed …

Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells

L Mutschelknaus, O Azimzadeh, T Heider, K Winkler… - Scientific reports, 2017 - nature.com
Radiation is a highly efficient therapy in squamous head and neck carcinoma (HNSCC)
treatment. However, local recurrence and metastasis are common complications. Recent …

Exosomes in cancer radioresistance

J Ni, J Bucci, D Malouf, M Knox, P Graham… - Frontiers in oncology, 2019 - frontiersin.org
Radiation is a mainstay of cancer therapy. Radioresistance is a significant challenge in the
treatment of locally advanced, recurrent and metastatic cancers. The mechanisms of …