Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Abstract 'Smart'bandages based on multimodal wearable devices could enable real-time
physiological monitoring and active intervention to promote healing of chronic wounds …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

INTRODUCTION Skin wounds generally heal by scarring, a fibrotic process mediated by the
Engrailed-1 (En1) fibroblast lineage. Scars differ from normal unwounded skin in three …

In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …