Immunotherapy is a milestone in the treatment of poor-prognosis pediatric acute
lymphoblastic leukemia (ALL) and is expected to improve treatment outcomes and reduce …

Simple Summary The survival rate for pediatric cancers has improved significantly over the
last decades. Conventional chemotherapies play a vital role in pediatric cancer treatment …

Vincristine (VCR), an effective antitumor drug, has been utilized in several polytherapy
regimens for acute lymphoblastic leukemia, neuroblastoma and rhabdomyosarcoma …

The human gut microbiota is a complex ecosystem that plays a crucial role in promoting the
interaction between the body and its environment. It has been increasingly recognized that …

Cancer is the leading cause of disease-related death among children. Vincristine (VCR), a
key component of childhood cancer treatment protocols, is associated with the risk of …

急性淋巴细胞白血病（ acute lymphoblastic leukemia， ALL） 是儿童期最常见的恶性肿瘤性疾病
。 随着临床诊治水平的不断提高， 获得完全缓解后长期生存的ALL 儿童越来越多 …

Patients with high-risk neuroblastoma (HR-NB) exhibit suboptimal 5-year survival rates,
leading to a widespread international preference for high-intensity chemotherapeutic …

Vincristine-induced peripheral neuropathy (VIPN) adversely affects the quality of life and
treatment continuity of patients. The endothelial glycocalyx (eGCX) protects nerves from …

To model peripheral nerve degeneration and investigate molecular mechanisms of
neurodegeneration, we established a cell system of induced pluripotent stem cell (iPSC) …

Background Vincristine (VCR)-induced peripheral neuropathy (VIPN) is a common adverse
reaction during cancer treatment, typically characterized by numbness and paresthesias …