Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption
AC Haigis, L Vergauwen, CA LaLone… - Toxicological …, 2023 - academic.oup.com
Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …
[HTML][HTML] Endocrine disruption assessment in aquatic vertebrates–Identification of substance-induced thyroid-mediated effect patterns
L Lagadic, KK Coady, O Körner, TJ Miller… - Environment …, 2024 - Elsevier
Abstract According to the World Health Organisation and European Commission definitions,
substances shall be considered as having endocrine disrupting properties if they show …
substances shall be considered as having endocrine disrupting properties if they show …
Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo
To better understand endocrine disruption, the US Environmental Protection Agency's
(USEPA) Endocrine Disruptor Screening Program (EDSP) utilizes a two-tiered approach to …
(USEPA) Endocrine Disruptor Screening Program (EDSP) utilizes a two-tiered approach to …
Biotransformation of Dec-604 and potential effect on thyroid deiodinase activity in highly flame retardant-exposed gulls
M Lépine, J Verreault - Environmental Research, 2022 - Elsevier
Several halogenated flame retardants (HFRs) have been identified as thyroid disruptors in
birds including the polybrominated diphenyl ether (PBDE) mixtures, which have been …
birds including the polybrominated diphenyl ether (PBDE) mixtures, which have been …
Antibodies regulate dual-function enzyme IYD to induce functional synergy between metabolism and thermogenesis
Iodotyrosine deiodinase (IYD) is a type of deiodinase enzyme that scavenges iodide from
the thyroid gland. Previously, we showed that H3 Ab acts as an agonist on IYD to induce …
the thyroid gland. Previously, we showed that H3 Ab acts as an agonist on IYD to induce …
[HTML][HTML] A 2024 inventory of test methods relevant to thyroid hormone system disruption for human health and environmental regulatory hazard assessment
Thyroid hormone system disruption (THSD) is a growing concern in chemical hazard
assessment due to its impact on human and environmental health and the scarce methods …
assessment due to its impact on human and environmental health and the scarce methods …