The multiple endocrine functions of bone other than those related to mineral metabolism,
such as regulation of insulin sensitivity, glucose homeostasis, and energy metabolism, have …

So far, the connections between obesity and skeleton have been extensively explored, but
the results are inconsistent. Obesity is thought to affect bone health through a variety of …

Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have …

Obesity develops when energy intake exceeds energy expenditure. Although most current
obesity therapies are focused on reducing calorific intake, recent data suggest that …

Bone morphogenetic protein (BMP) signals coordinate developmental patterning and have
essential physiological roles in mature organisms. Here we describe the first known small …

Activated fibroblasts are key contributors to the fibrotic extracellular matrix accumulation
during liver fibrosis. The origin of such fibroblasts is still debated, although several studies …

Angiogenesis is a complex process, requiring a finely tuned balance between numerous
stimulatory and inhibitory signals. ALK1 (activin receptor like-kinase 1) is an endothelial …

EMT/MET occur when tissues are being built or remodeled. Hence, EMT/MET are involved
in (1) embryogenesis/development,(2) wound healing/tissue regeneration/organ fibrosis …

The capability of the liver to fully regenerate after injury is a unique phenomenon essential
for the maintenance of its important functions in the control of metabolism and xenobiotic …

Connective tissue growth factor (CTGF= CCN2), one of six members of cysteine‐rich,
secreted, heparin‐binding proteins with a modular structure, is recognized as an important …