Current strategies in assessment of nanotoxicity: alternatives to in vivo animal testing
Millions of experimental animals are widely used in the assessment of toxicological or
biological effects of manufactured nanomaterials in medical technology. However, the …
biological effects of manufactured nanomaterials in medical technology. However, the …
Primary cell-derived intestinal models: recapitulating physiology
The development of physiologically relevant intestinal models fueled by breakthroughs in
primary cell-culture methods has enabled successful recapitulation of key features of …
primary cell-culture methods has enabled successful recapitulation of key features of …
Suppressive and gut-reparative functions of human type 1 T regulatory cells
Background & Aims T-regulatory (Treg) cells suppress the immune response to maintain
homeostasis. There are 2 main subsets of Treg cells: FOXP3 (forkhead box protein 3) …
homeostasis. There are 2 main subsets of Treg cells: FOXP3 (forkhead box protein 3) …
Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation
Endoplasmic reticulum (ER) stress compromises the secretion of MUC2 from goblet cells
and has been linked with inflammatory bowel disease (IBD). Although Bifidobacterium can …
and has been linked with inflammatory bowel disease (IBD). Although Bifidobacterium can …
[HTML][HTML] Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes
SM Crowley, X Han, JM Allaire, M Stahl, I Rauch… - PLoS …, 2020 - journals.plos.org
We investigated the role of the inflammasome effector caspases-1 and-11 during
Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells …
Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells …
[HTML][HTML] Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids
B van der Hee, LMP Loonen, N Taverne… - Stem cell …, 2018 - Elsevier
An important practical limitation of the three-dimensional geometry of stem-cell derived
intestinal organoids is that it prevents easy access to the apical epithelium for testing food …
intestinal organoids is that it prevents easy access to the apical epithelium for testing food …
DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk
H Grasberger, AT Magis, E Sheng… - The Journal of …, 2021 - Am Soc Clin Investig
A primordial gut-epithelial innate defense response is the release of hydrogen peroxide by
dual NADPH oxidase (DUOX). In inflammatory bowel disease (IBD), a condition …
dual NADPH oxidase (DUOX). In inflammatory bowel disease (IBD), a condition …
Immunomodulation of dendritic cells by Lactobacillus reuteri surface components and metabolites
Background Lactic acid bacteria are commensal members of the gut microbiota and are
postulated to promote host health. Secreted factors and cell surface components from …
postulated to promote host health. Secreted factors and cell surface components from …
Dclk1 in tuft cells promotes inflammation-driven epithelial restitution and mitigates chronic colitis
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by defective
intestinal barrier integrity toward the microbiota and epithelial damage. Double cortin-like …
intestinal barrier integrity toward the microbiota and epithelial damage. Double cortin-like …
Targeting the pregnane X receptor using microbial metabolite mimicry
Z Dvořák, F Kopp, CM Costello, JS Kemp… - EMBO molecular …, 2020 - embopress.org
The human PXR (pregnane X receptor), a master regulator of drug metabolism, has
essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands …
essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands …