JS Dutton, SS Hinman, R Kim, Y Wang… - Trends in …, 2019 - cell.com
The development of physiologically relevant intestinal models fueled by breakthroughs in primary cell-culture methods has enabled successful recapitulation of key features of …
Background & Aims T-regulatory (Treg) cells suppress the immune response to maintain homeostasis. There are 2 main subsets of Treg cells: FOXP3 (forkhead box protein 3) …
Endoplasmic reticulum (ER) stress compromises the secretion of MUC2 from goblet cells and has been linked with inflammatory bowel disease (IBD). Although Bifidobacterium can …
SM Crowley, X Han, JM Allaire, M Stahl, I Rauch… - PLoS …, 2020 - journals.plos.org
We investigated the role of the inflammasome effector caspases-1 and-11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells …
B van der Hee, LMP Loonen, N Taverne… - Stem cell …, 2018 - Elsevier
An important practical limitation of the three-dimensional geometry of stem-cell derived intestinal organoids is that it prevents easy access to the apical epithelium for testing food …
H Grasberger, AT Magis, E Sheng… - The Journal of …, 2021 - Am Soc Clin Investig
A primordial gut-epithelial innate defense response is the release of hydrogen peroxide by dual NADPH oxidase (DUOX). In inflammatory bowel disease (IBD), a condition …
Background Lactic acid bacteria are commensal members of the gut microbiota and are postulated to promote host health. Secreted factors and cell surface components from …
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by defective intestinal barrier integrity toward the microbiota and epithelial damage. Double cortin-like …
Z Dvořák, F Kopp, CM Costello, JS Kemp… - EMBO molecular …, 2020 - embopress.org
The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands …