Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with
excessive deposition of extracellular matrix and connective tissue at the site of injury. In this …

COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory …

Scar formation is an intractable medical problem that appears after skin wounds have
healed. Recent research has shown that exosomes secreted by human adipose …

Scar formation is a common consequence of skin injuries that lead to a wide range of
adverse effects including physical deformities and psychological disorders. Studies …

The repair of wounds is one of the most complex biological processes that occur during
human life. After an injury, multiple biological pathways immediately become activated and …

Significance: Poor wound healing remains a significant health issue for a large number of
patients in the United States. The physiologic response to local wound hypoxia plays a …

Scar formation is a consequence of the wound healing process that occurs when body
tissues are damaged by a physical injury. Hypertrophic scars and keloids are pathological …

Significance: Excessive scarring is major clinical and financial burden in the United States.
Improved therapies are necessary to reduce scarring, especially in patients affected by …

Burns are the most extensive forms of soft tissue injuries occasionally resulting in extensive
and deep wounds and death. Burns can lead to severe mental and emotional distress …

The engineering of skin substitutes and their application on human patients has become a
reality. However, cell biologists, biochemists, technical engineers, and surgeons are still …