Human antibodies for viral infections

JE Crowe Jr - Annual review of immunology, 2022 - annualreviews.org
Antibodies have been used to prevent or treat viral infections since the nineteenth century,
but the full potential to use passive immunization for infectious diseases has yet to be …

Henipavirus zoonosis: outbreaks, animal hosts and potential new emergence

H Li, JYV Kim, BS Pickering - Frontiers in microbiology, 2023 - frontiersin.org
Hendra virus (HeV) and Nipah virus (NiV) are biosafety level 4 zoonotic pathogens causing
severe and often fatal neurological and respiratory disease. These agents have been …

Architecture and antigenicity of the Nipah virus attachment glycoprotein

Z Wang - Biophysical Journal, 2022 - cell.com
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic zoonotic henipaviruses
(HNVs) responsible for recurrent outbreaks of encephalitis and respiratory illness. As the …

[HTML][HTML] Novel Hendra virus variant detected by sentinel surveillance of horses in Australia

EJ Annand, BA Horsburgh, K Xu, PA Reid… - Emerging infectious …, 2022 - ncbi.nlm.nih.gov
We identified and isolated a novel Hendra virus (HeV) variant not detected by routine testing
from a horse in Queensland, Australia, that died from acute illness with signs consistent with …

Structure and design of Langya virus glycoprotein antigens

Z Wang, M McCallum, L Yan… - Proceedings of the …, 2024 - National Acad Sciences
Langya virus (LayV) is a recently discovered henipavirus (HNV), isolated from febrile
patients in China. HNV entry into host cells is mediated by the attachment (G) and fusion (F) …

Chimeric fusion (F) and attachment (G) glycoprotein antigen delivery by mRNA as a candidate Nipah vaccine

RJ Loomis, AT DiPiazza, S Falcone… - Frontiers in …, 2021 - frontiersin.org
Nipah virus (NiV) represents a significant pandemic threat with zoonotic transmission from
bats-to-humans with almost annual regional outbreaks characterized by documented human …

Potent monoclonal antibody–mediated neutralization of a divergent Hendra virus variant

Z Wang, HV Dang, M Amaya, Y Xu… - Proceedings of the …, 2022 - National Acad Sciences
Hendra virus (HeV) and Nipah virus (NiV) are deadly zoonotic Henipaviruses (HNVs)
responsible for recurrent outbreaks in humans and domestic species of highly fatal (50 to …

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

TB Engdahl, E Binshtein, RL Brocato, NA Kuzmina… - Elife, 2023 - elifesciences.org
Hantaviruses are high-priority emerging pathogens carried by rodents and transmitted to
humans by aerosolized excreta or, in rare cases, person-to-person contact. While infections …

The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus

Y Guo, S Wu, W Li, H Yang, T Shi, B Ju, Z Zhang… - Nature …, 2024 - nature.com
Abstract Langya Henipavirus (LayV) infection is an emerging zoonotic disease that has
been causing respiratory symptoms in China since 2019. For virus entry, LayV's genome …

In vivo electroporation of plasmid DNA: a promising strategy for rapid, inexpensive, and flexible delivery of anti-viral monoclonal antibodies

S Pagant, RA Liberatore - Pharmaceutics, 2021 - mdpi.com
Since the first approval of monoclonal antibodies by the United States Food and Drug
Administration (FDA) in 1986, therapeutic antibodies have become one of the predominant …