Obesity, insulin resistance, and type 2 diabetes: associations and therapeutic implications

YT Wondmkun - Diabetes, Metabolic Syndrome and Obesity, 2020 - Taylor & Francis
Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals
who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro …

The effects of obesity on skeletal muscle contractile function

J Tallis, RS James… - Journal of Experimental …, 2018 - journals.biologists.com
Obesity can cause a decline in contractile function of skeletal muscle, thereby reducing
mobility and promoting obesity-associated health risks. We reviewed the literature to …

Prevalence and mechanisms of skeletal muscle atrophy in metabolic conditions

L Jun, M Robinson, T Geetha, TL Broderick… - International Journal of …, 2023 - mdpi.com
Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as
diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer's …

[HTML][HTML] Exploring the impact of obesity on skeletal muscle function in older age

PT Morgan, B Smeuninx, L Breen - Frontiers in Nutrition, 2020 - frontiersin.org
Sarcopenia is of important clinical relevance for loss of independence in older adults. The
prevalence of obesity in combination with sarcopenia ('sarcopenic-obesity') is increasing at …

High-fat diet suppresses the positive effect of creatine supplementation on skeletal muscle function by reducing protein expression of IGF-PI3K-AKT-mTOR pathway

R Ferretti, EG Moura, VC Dos Santos, EJ Caldeira… - PloS one, 2018 - journals.plos.org
High-fat (HF) diets in combination with sedentary lifestyle represent one of the major public
health concerns predisposing to obesity and diabetes leading to skeletal muscle atrophy …

Leptin mediates the regulation of muscle mass and strength by adipose tissue

KH Collins, C Gui, EV Ely, KL Lenz… - The Journal of …, 2022 - Wiley Online Library
Adipose tissue secretes numerous cytokines (termed 'adipokines') that have known or
hypothesized actions on skeletal muscle. The majority of adipokines have been implicated …

Effects of different resistance exercise forms on body composition and muscle strength in overweight and/or obese individuals: a systematic review and meta-analysis

X Liu, Y Gao, J Lu, Q Ma, Y Shi, J Liu, S Xin… - Frontiers in …, 2022 - frontiersin.org
Purpose This study is a systematic review and meta-analysis to determine the effects of
different forms of resistance training on body composition and muscle strength in overweight …

The association between excess body mass and disturbances in somatic mineral levels

W Banach, K Nitschke, N Krajewska… - International Journal of …, 2020 - mdpi.com
Background: Obesity and excess body weight are significant epidemiological issues, not
only because they are costly to treat, but also because they are among the leading causes of …

Metabolic networks influencing skeletal muscle fiber composition

I Bourdeau Julien, CF Sephton… - Frontiers in cell and …, 2018 - frontiersin.org
Advancements in metabolomic and genomic research tools are revealing new insights into
how metabolic networks can influence skeletal muscle fiber composition. In this mini-review …

The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles

GAM Messa, M Piasecki, J Hurst, C Hill… - Journal of …, 2020 - journals.biologists.com
Prolonged high-fat diets (HFDs) can cause intramyocellular lipid (IMCL) accumulation that
may negatively affect muscle function. We investigated the duration of a HFD required to …