The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a non-
cell autonomous motor neuron loss. While it is generally believed that the disease onset …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motoneurons in
the cerebral cortex, brainstem and spinal cord. Neuroinflammation plays an important role in …

Based on promising preclinical evidence, microglial P2X7 has increasingly being
recognized as a target for therapeutic intervention in neurological and psychiatric diseases …

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motoneurons
and degradation of the neuromuscular junctions (NMJ). Consistent with the dying-back …

Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor
neuron degeneration and disease progression in rodent models of mutant superoxide …

Neurodegenerative diseases (NDDs) represent a huge social burden, particularly in
Alzheimer's disease (AD) in which all proposed treatments investigated in murine models …