The dysfunction of the ubiquitin–proteasome system (UPS) facilitates the malignant
progression of hepatocellular carcinoma (HCC). While targeting the UPS for HCC therapy …

Dysregulation of WNT/β-catenin is a hallmark of many cancer types and a key mediator of
metastasis in solid tumors. Overactive β-catenin signaling hampers dendritic cell (DC) …

Deubiquitinating enzymes (DUBs) regulate substrate ubiquitination by removing ubiquitin or
cleaving within ubiquitin chains, thereby maintaining cellular homeostasis. Approximately …

The control of Wnt receptor abundance is critical for animal development and to prevent
tumorigenesis, but the mechanisms that mediate receptor stabilization remain uncertain. We …

Pancreatic ductal adenocarcinoma (PDAC) is highly malignant and has a poor prognosis,
without effective therapeutic targets in common gene mutations. Gemcitabine, a first-line …

Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic
response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators …

Signaling through the Wnt/β‐catenin pathway is relayed through three multiprotein
complexes:(1) the membrane‐associated signalosome, which includes the activated Wnt …

Pancreatic cancer is a highly malignant tumor characterized by high mortality and low
survival rates. The mitotic interactor and substrate of Plk1 (MISP) is a cancer-associated …

The COVID-19 pandemic prompted rapid research on SARS-CoV-2 pathogenicity.
Consequently, new data can be used to advance the molecular understanding of SARS …

Ubiquitination is an enzymatic process characterized by the covalent attachment of ubiquitin
to target proteins, thereby modulating their degradation, transportation, and signal …