Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute
stress. They are best known as inducible transcriptional regulators of genes encoding …

To dampen proteotoxic stresses and maintain protein homeostasis, organisms possess a
stress-responsive molecular machinery that detects and neutralizes protein damage. A …

Intermittent fasting (IF; reduced meal frequency) and caloric restriction (CR) extend lifespan
and increase resistance to age-related diseases in rodents and monkeys and improve the …

Parkinson's disease (PD) is an age‐related disorder characterized by progressive
degeneration of dopaminergic neurons in the substantia nigra (SN) and corresponding …

Exercise, a behavior that is inherently associated with energy metabolism, impacts the
molecular systems important for synaptic plasticity and learning and memory. This implies …

Food restriction (FR) in rodents is known to extend life span, reduce the incidence of age‐
related tumors, and suppress oxidative damage to proteins, lipids, and DNA in several organ …

This study characterizes mitochondria isolated from livers of Sod2−/+ and Sod2+/+ mice. A
50% decrease in manganese superoxide dismutase (MnSOD) activity was observed in …

Every cell has developed mechanisms to respond to changes in its environment and to
adapt its growth and metabolism to unfavorable conditions. The unicellular eukaryote yeast …

Abstract.—The disposable soma theory suggests that aging occurs because natural
selection favors a strategy in which fewer resources are invested in somatic maintenance …

▪ Abstract The size and frequency of meals are fundamental aspects of nutrition that can
have profound effects on the health and longevity of laboratory animals. In humans …