The post-translational modification of proteins expands the regulatory scope of the proteome
far beyond what is achievable through genome regulation. The field of protein citrullination …

Proteins once translated are subjected to post-translational modifications (PTMs) that can
critically modify their characteristics. Citrullination is a unique type of PTM that is catalysed …

Protein citrullination is accomplished by a broad enzyme family named Peptidyl Arginine
Deiminases (PADs), which makes this post-translational modification in many proteins that …

Peptidylarginine deiminases (PADs) are the only enzyme class known to deiminate arginine
residues into citrulline in proteins, a process known as citrullination. This is an important post …

Background Dilated cardiomyopathy (DCM) is characterized by enlarged, weakened heart
ventricles due to chronic fibrosis. Dysfunctional senescent myofibroblasts and excessive …

Human corneal fibrosis can lead to opacity and ultimately partial or complete vision loss.
Currently, corneal transplantation is the only treatment for severe corneal fibrosis and comes …

Introduction The extracellular matrix (ECM) is a highly organized and dynamic network of
proteins and glycosaminoglycans that provides critical structural, mechanical, and …

Introduction MZB1 is an endoplasmic reticulum residential protein preferentially expressed
in plasma cells, marginal zone and B1 B cells. Recent studies on murine B cells show that it …

The peptidyl arginine deiminase (PADI) family is a calcium ion-dependent group of
isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can …

The present review aims to describe the state of the art of research studies investigating the
citrullination post-translational modification in adult and pediatric brain tumors. After an …