Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a …

The mammalian circadian system consists of a master clock in the brain that synchronizes
subsidiary oscillators in peripheral tissues. The master clock maintains phase coherence in …

Daily rhythms in animal physiology are driven by endogenous circadian clocks in part
through rest-activity and feeding-fasting cycles. Here, we examined principles that govern …

Blood pressure, renal hemodynamics, electrolyte, and water excretion all display diurnal
oscillation. Disturbance of these patterns is associated with hypertension and chronic kidney …

Curcumin exhibits several therapeutic properties. Potassium dichromate (K 2 Cr 2 O 7)-
induced nephropathy is associated with oxidative stress. Reactive oxygen species …

Key points Our understanding of the mechanisms underlying the role of hypoxia in the
initiation and progression of renal disease remains rudimentary. We have developed a …

Intramedullary pressure increases after spinal cord injury, and this can be an important
factor for secondary spinal cord injury. Until now there have been no studies of the dynamic …

Renal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of
acute kidney injury of various origins, and may also promote progression from acute injury to …

Tissue hypoxia has been proposed as an important event in renal ischemia-reperfusion
injury (IRI), particularly during the period of ischemia and in the immediate hours following …

Background Renal hypoxia, implicated as crucial factor in onset and progression of chronic
kidney disease, may be attributed to reduced nitric oxide because nitric oxide dilates …