PCSK9 inhibitors in cancer patients treated with immune-checkpoint inhibitors to reduce cardiovascular events: new frontiers in cardioncology
V Quagliariello, I Bisceglia, M Berretta, M Iovine… - Cancers, 2023 - mdpi.com
Simple Summary Atherosclerosis is a critical cardiovascular disease associated with the use
of immune checkpoint inhibitors (ICIs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) …
of immune checkpoint inhibitors (ICIs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) …
The multifaceted role of PCSK9 in cancer pathogenesis, tumor immunity, and immunotherapy
CY Hsu, MN Abdulrahim, MA Mustafa, TM Omar… - Medical Oncology, 2024 - Springer
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a well-known regulator of cholesterol
metabolism and cardiovascular diseases, has recently garnered attention for its emerging …
metabolism and cardiovascular diseases, has recently garnered attention for its emerging …
Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study
Background Prostate cancer (PrCa) is the second most prevalent malignancy in men
worldwide. Observational studies have linked the use of low-density lipoprotein cholesterol …
worldwide. Observational studies have linked the use of low-density lipoprotein cholesterol …
[HTML][HTML] Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer
QC Yang, S Wang, YT Liu, A Song, ZZ Wu, SC Wan… - Iscience, 2023 - cell.com
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been demonstrated to play a
critical role in regulating cholesterol homeostasis and T cell antitumor immunity. However …
critical role in regulating cholesterol homeostasis and T cell antitumor immunity. However …
[HTML][HTML] Theoretical Framework and Emerging Challenges of Lipid Metabolism in Cancer
Q Gu, Y Wang, P Yi, C Cheng - Seminars in Cancer Biology, 2024 - Elsevier
Elevated lipid metabolism is one of hallmarks of malignant tumors. Lipids not only serve as
essential structural components of biological membranes but also provide energy and …
essential structural components of biological membranes but also provide energy and …
Dyslipidemia, lipid-lowering agents and neuroendocrine neoplasms: new horizons
R Modica, A La Salvia, A Liccardi, A Cozzolino… - Endocrine, 2024 - Springer
Abstract Purpose Neuroendocrine neoplasms (NENs) are a heterogeneous group of
malignancies originating from cells with a neuroendocrine phenotype. The complex …
malignancies originating from cells with a neuroendocrine phenotype. The complex …
High levels of serum cholesterol positively correlate with the risk of the development of vessel co-opting tumours in colorectal cancer liver metastases
M Rada, L Krzywon, A Kapelanski-Lamoureux… - MedRxiv, 2022 - medrxiv.org
Colorectal cancer liver metastatic (CRCLM) tumours present as two main histopathological
growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP …
growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP …
PCSK9 facilitates melanoma pathogenesis via a network regulating tumor immunity
Background PCSK9 regulates cholesterol homeostasis and promotes tumorigenesis.
However, the relevance of these two actions and the mechanisms underlying PCSK9's …
However, the relevance of these two actions and the mechanisms underlying PCSK9's …
Inhibition of proprotein convertase subtilisin-like kexin type 9 (PCSK9) potentiates anti-angiogenic therapy in colorectal cancer liver metastases
Colorectal cancer liver metastatic (CRCLM) tumours present as two main histopathological
growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP …
growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP …
Towards developing novel prostate cancer recurrence suppressors: acute toxicity of pseurotin a, an orally active PCSK9 axis-targeting small-molecule in swiss albino …
The proprotein convertase subtilisin kexin type 9 (PCSK9) emerged as a molecular target of
great interest for the management of cardiovascular disorders due to its ability to reduce low …
great interest for the management of cardiovascular disorders due to its ability to reduce low …