Mechanistic modeling of SARS‐CoV‐2 and other infectious diseases and the effects of therapeutics

AS Perelson, R Ke - Clinical Pharmacology & Therapeutics, 2021 - Wiley Online Library
Modern viral kinetic modeling and its application to therapeutics is a field that attracted the
attention of the medical, pharmaceutical, and modeling communities during the early days of …

SARS‐CoV‐2 coinfections: Could influenza and the common cold be beneficial?

L Pinky, HM Dobrovolny - Journal of Medical Virology, 2020 - Wiley Online Library
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has
rapidly spread around the world, causing serious illness and death and creating a heavy …

How robust are estimates of key parameters in standard viral dynamic models?

C Zitzmann, R Ke, RM Ribeiro… - PLOS Computational …, 2024 - journals.plos.org
Mathematical models of viral infection have been developed, fitted to data, and provide
insight into disease pathogenesis for multiple agents that cause chronic infection, including …

Respiratory Syncytial Virus Infection Modeled in Aging Cotton Rats (Sigmodon hispidus) and Mice (Mus musculus)

OE Harder, S Niewiesk - Advances in Virology, 2022 - Wiley Online Library
Serious infection with respiratory syncytial virus (RSV) is associated with high risk in infants,
children, and elderly. There is currently no approved vaccine against RSV infection, and the …

Initial inoculum and the severity of COVID-19: A mathematical modeling study of the dose-response of SARS-CoV-2 infections

B Fain, HM Dobrovolny - Epidemiologia, 2020 - mdpi.com
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) causes a variety of
responses in those who contract the virus, ranging from asymptomatic infections to acute …

[HTML][HTML] Estimation of virus-mediated cell fusion rate of SARS-CoV-2

A Amidei, HM Dobrovolny - Virology, 2022 - Elsevier
Several viruses have the ability to form large multinucleated cells known as syncytia. Many
properties of syncytia and the role they play in the evolution of a viral infection are not well …

Quantifying dose-, strain-, and tissue-specific kinetics of parainfluenza virus infection

L Pinky, CW Burke, CJ Russell… - PLOS Computational …, 2021 - journals.plos.org
Human parainfluenza viruses (HPIVs) are a leading cause of acute respiratory infection
hospitalization in children, yet little is known about how dose, strain, tissue tropism, and …

The role of syncytia during viral infections

B Jessie, HM Dobrovolny - Journal of Theoretical Biology, 2021 - Elsevier
Respiratory syncytial virus (RSV) is a common, contagious infection of the lungs and the
respiratory tract. RSV is characterized by syncytia, which are multinuclear cells created by …

Prostaglandin D2 delays CD8+ T-cell responses and respiratory syncytial virus clearance in geriatric cotton rats

JL Miller, C Leedale, D Kang, J Lilue… - Journal of …, 2025 - journals.asm.org
Respiratory syncytial virus (RSV) infection is associated with increased rates of severe
disease, hospitalization, and death in elderly individuals. Clearance of RSV is frequently …

Pulmonary function analysis in cotton rats after respiratory syncytial virus infection

ME Martinez, OE Harder, LE Rosas, L Joseph… - PloS one, 2020 - journals.plos.org
The cotton rat (Sigmodon hispidus) is an excellent small animal model for human respiratory
viral infections such as human respiratory syncytial virus (RSV) and human …