Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla
of life. Accumulating evidence indicates that sirtuins are important regulators of organism life …

1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …

The Saccharomyces cerevisiae Sir2 protein is an NAD+-dependent histone deacetylase that
plays a critical role in transcriptional silencing, genome stability, and longevity. A human …

NAD+ is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a
source of ADPribosyl groups used in various reactions, including those that retard aging in …

Recent studies have revealed new roles for NAD and its derivatives in transcriptional
regulation. The evolutionarily conserved Sir2 protein family requires NAD for its deacetylase …

Calorie restriction extends lifespan in a broad range of organisms, from yeasts to mammals.
Numerous hypotheses have been proposed to explain this phenomenon, including …

▪ Abstract Genomes are organized into active regions known as euchromatin and inactive
regions known as heterochromatin, or silenced chromatin. This review describes …

Sir2 enzymes form a unique class of NAD+-dependent deacetylases required for diverse
biological processes, including transcriptional silencing, regulation of apoptosis, fat …

Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that
participates in many metabolic reactions. Recent studies show that NAD also plays …

Although NAD+ biosynthesis is required for Sir2 functions and replicative lifespan in yeast,
alterations in NAD+ precursors have been reported to accelerate aging but not to extend …