Airway hyperresponsiveness (AHR) is characterized by excessive bronchoconstriction in
response to nonspecific stimuli, thereby leading to airway stenosis and increased airway …

Cancer is frequently dependent on aberrant gene expression programs that might be
vulnerable to targeting with novel therapeutics. Bromodomain and extraterminal domain …

Naive CD4+ T lymphocytes initially undergo antigen-specific activation to promote a broad-
spectrum response before adopting bespoke cytokine expression profiles shaped by …

Effective therapeutics are urgently needed to counter infection and improve outcomes for
patients suffering from COVID-19 and to combat this pandemic. Manipulation of epigenetic …

Introduction: Asthma is a chronic disease of the airways that impairs normal breathing. The
etiology of asthma is complex and involves multiple factors, including the environment and …

Migration and homing of immune cells are critical for immune surveillance. Trafficking is
mediated by combinations of adhesion and chemokine receptors that guide immune cells, in …

Natural killer (NK) cells are innate lymphocytes that play a pivotal role in the immune
surveillance and elimination of transformed or virally infected cells. Using a chemo-genetic …

Epigenetic modifications include DNA methylation, histone modification and the action of
microRNAs. These mechanisms coordinate in complex networks to control gene expression …

Epidemiological research has identified that exposure to fine particulate matter (PM2. 5) can
increase airway hyperresponsiveness (AHR) which is considered a typical characteristic of …

Abstract Context Modified BuShenYiQi formula (M-BYF) is derived from BuShenYiQi
formula, used for the treatment of allergic asthma. The exact effect and mechanism of M-BYF …