Regeneration of pancreatic beta cells by modulation of molecular targets using plant-derived compounds: pharmacological mechanisms and clinical potential
Type 2 diabetes (T2D) is characterized by pancreatic beta-cell dysfunction, increased cell
death and loss of beta-cell mass despite chronic treatment. Consequently, there has been …
death and loss of beta-cell mass despite chronic treatment. Consequently, there has been …
Lineage reprogramming: a promising road for pancreatic β cell regeneration
R Wei, T Hong - Trends in Endocrinology & Metabolism, 2016 - cell.com
Cell replacement therapy is a promising method to restore pancreatic β cell function and
cure diabetes. Distantly related cells (fibroblasts, keratinocytes, and muscle cells) and …
cure diabetes. Distantly related cells (fibroblasts, keratinocytes, and muscle cells) and …
Taming food–drug interaction risk: Potential inhibitory effects of citrus juices on cytochrome liver enzymes can safeguard the liver from overdose paracetamol-induced …
Paracetamol overdose is the leading cause of drug-induced hepatotoxicity worldwide.
Because of N-acetyl cysteine's limited therapeutic efficacy and safety, searching for …
Because of N-acetyl cysteine's limited therapeutic efficacy and safety, searching for …
Swertiamarin: An Active Lead from Enicostemma littorale Regulates Hepatic and Adipose Tissue Gene Expression by Targeting PPAR‐γ and Improves Insulin …
Enicostemma littorale (EL) Blume is one of the herbs widely used for treating and alleviating
the effects of both type I and type II diabetes. However, lack of understanding of mechanism …
the effects of both type I and type II diabetes. However, lack of understanding of mechanism …
Swertisin an anti-diabetic compound facilitate islet neogenesis from pancreatic stem/progenitor cells via p-38 MAP kinase-SMAD pathway: an in-vitro and in-vivo study
Transplanting islets serves best option for restoring lost beta cell mass and function. Small
bio-chemical agents do have the potential to generate new islets mass, however lack of …
bio-chemical agents do have the potential to generate new islets mass, however lack of …
Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property
Swertisin, a C-glucosylflavone isolated from Swertia japonica, has been known to have anti-
inflammatory or antidiabetic activities. Until yet, however, its cognitive function is not …
inflammatory or antidiabetic activities. Until yet, however, its cognitive function is not …
Direct lineage tracing reveals Activin-a potential for improved pancreatic homing of bone marrow mesenchymal stem cells and efficient ß-cell regeneration in vivo
Background Despite the potential, bone marrow-derived mesenchymal stem cells (BMSCs)
show limitations for beta (ß)-cell replacement therapy due to inefficient methods to deliver …
show limitations for beta (ß)-cell replacement therapy due to inefficient methods to deliver …
[HTML][HTML] Swertisin ameliorates diabetes by triggering pancreatic progenitors for islet neogenesis in Streptozotocin treated BALB/c mice
In the present study, Swertisin's role in triggering resident pancreatic progenitors for islet
neogenesis in Streptozotocin (STZ) diabetic mice was explored. STZ diabetic mice when …
neogenesis in Streptozotocin (STZ) diabetic mice was explored. STZ diabetic mice when …
[HTML][HTML] HPTLC quantification, assessment of antioxidant potential and in vivo hypoglycemic activity of Scorzonera latifolia (Fisch. & CA Mey.) DC. and its major …
NIK Sonmez, OB Acikara, AA Sakul, BC Bahtiyar… - South African Journal of …, 2022 - Elsevier
Scorzonera L.(Asteraceae) species have long been the topic of many phytochemical,
analytical, and biological studies since various species of the Scorzonera genus have been …
analytical, and biological studies since various species of the Scorzonera genus have been …
[HTML][HTML] Molecules and targets of antidiabetic interest
K Gawli, KS Bojja - Phytomedicine Plus, 2024 - Elsevier
Background The review is a comprehensive overview of targets of antidiabetic interest and
molecules that are reported to possess modulatory effects on glucose homeostasis. Drugs …
molecules that are reported to possess modulatory effects on glucose homeostasis. Drugs …