Cytosine base editors and adenine base editors (ABEs) can correct point mutations
predictably and independent of Cas9-induced double-stranded DNA breaks (which causes …

Vitamin A is an essential nutrient necessary for numerous basic physiological functions,
including reproduction and development, immune cell differentiation and communication, as …

Leber congenital amaurosis (LCA) is the most common cause of inherited retinal
degeneration in children. LCA patients with RPE65 mutations show accelerated cone …

There is increasing recognition that dietary lipids can affect the expression of genes
encoding their metabolizing enzymes, transporters, and binding proteins. This mechanism …

RPE65 is the essential trans–cis isomerase of the classical retinoid (visual) cycle. Mutations
in RPE65 give rise to severe retinal dystrophies, most of which are associated with loss of …

Rhodopsin (Rho) and cone opsins are essential for detection of light. They respond via
photoisomerization, converting their Schiff-base-adducted 11-cis-retinylidene chromophores …

Purpose: We developed and phenotyped a pigmented knockout rat model for lecithin retinol
acyltransferase (LRAT) using CRISPR/Cas9. The introduced mutation (c. 12delA) is based …

Lipid droplets are unique and nearly ubiquitous organelles that store neutral lipids in a
hydrophobic core, surrounded by a monolayer of phospholipids. The primary neutral lipids …

The two key cycles that are essential to sustain vision are the photocycle of visual opsins
and the retinoid or visual cycle. Visual opsins include rhodopsin and cone opsin, which are …

Retinol-binding proteins play a pivotal role for the regulation of the retinoid metabolism,
thereby influencing crucial physiological processes such as vision, cell division …