Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

Malaria chemoprevention and drug resistance: a review of the literature and policy implications

CV Plowe - Malaria Journal, 2022 - Springer
Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

A Uwimana, E Legrand, BH Stokes, JLM Ndikumana… - Nature medicine, 2020 - nature.com
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based
combination therapy), is widespread across Southeast Asia but to date has not been …

Drug resistance in Plasmodium

K Haldar, S Bhattacharjee, I Safeukui - Nature Reviews Microbiology, 2018 - nature.com
A marked decrease in malaria-related deaths worldwide has been attributed to the
administration of effective antimalarials against Plasmodium falciparum, in particular …

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

F Ariey, B Witkowski, C Amaratunga, J Beghain… - Nature, 2014 - nature.com
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

KJ Wicht, S Mok, DA Fidock - Annual review of microbiology, 2020 - annualreviews.org
Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …

Artemisinin action and resistance in Plasmodium falciparum

L Tilley, J Straimer, NF Gnädig, SA Ralph… - Trends in …, 2016 - cell.com
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

Antimalarial drug resistance and novel targets for antimalarial drug discovery

MA Shibeshi, ZD Kifle, SA Atnafie - Infection and drug resistance, 2020 - Taylor & Francis
Malaria is among the most devastating and widespread tropical parasitic diseases in which
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …

Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa

PJ Rosenthal, V Asua, MD Conrad - Nature Reviews Microbiology, 2024 - nature.com
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

[HTML][HTML] Antimalarial drug resistance: literature review and activities and findings of the ICEMR network

L Cui, S Mharakurwa, D Ndiaye… - The American journal …, 2015 - ncbi.nlm.nih.gov
Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …