PURPOSE: Sunburns are an important risk factor for melanoma and those occurring in
childhood are often cited as posing the greatest risk. We conducted a meta-analysis to …

The melanogenic actions of the melanocortins are mediated by the melanocortin‐1 receptor
(MC1R). MC1R is a member of the G‐protein‐coupled receptors (GPCR) superfamily …

Background: Clinical data indicate that estrogen receptor–positive/progesterone receptor–
negative (ER+/PR−) breast cancers are less sensitive to tamoxifen than are ER+/PR+ …

Abstract Melanocortin‐1‐receptor (MC1R) is one of the major genes that determine skin
pigmentation. MC1R variants were suggested to be associated with red hair, fair skin, and …

Skin pigmentation is one of the most overt human physical traits with consequences on
susceptibility to skin cancer. The variations in skin pigmentation are dependent on …

A family history of melanoma greatly increases the risk of developing cutaneous melanoma,
a highly aggressive skin cancer whose incidence has been steadily increasing worldwide …

Melanocortins are peptide hormones critical for the regulation of stress response, energy
homeostasis, inflammation, and skin pigmentation. Their functions are mediated by five G …

Cutaneous malignant melanoma (CMM) has been increasing steadily in incidence during
the past 30 years. Recent studies have explored associations between CMM and varying …

Polymorphisms in the melanocortin 1 receptor (MC1R) gene have been associated with
increased risks of melanoma, but different approaches to study design, analysis, and …

Skin cancer is a critical global public health concern, with melanoma being the deadliest
variant, correlated to 80% of skin cancer-related deaths and a remarkable propensity to …