Refining the role of 5-HT in postnatal development of brain circuits

A Teissier, M Soiza-Reilly, P Gaspar - Frontiers in cellular …, 2017 - frontiersin.org
Changing serotonin (5-hydroxytryptamine, 5-HT) brain levels during critical periods in
development has long-lasting effects on brain function, particularly on later …

The effects of maternal antidepressant use on offspring behaviour and brain development: Implications for risk of neurodevelopmental disorders

SJ Millard, K Weston-Green, KA Newell - Neuroscience & Biobehavioral …, 2017 - Elsevier
Approximately 10% of pregnant women are prescribed antidepressant drugs (ADDs), with
selective serotonin reuptake inhibitors (SSRIs) the most widely prescribed. SSRIs bind to the …

Activity of raphé serotonergic neurons controls emotional behaviors

A Teissier, A Chemiakine, B Inbar, S Bagchi, RS Ray… - Cell reports, 2015 - cell.com
Despite the well-established role of serotonin signaling in mood regulation, causal
relationships between serotonergic neuronal activity and behavior remain poorly …

Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring

JDA Olivier, A Valles, F van Heesch… - …, 2011 - Springer
Abstract Rationale Fluoxetine (Prozac®) is the most frequently prescribed drug to battle
depression in pregnant women, but its safety in the unborn child has not yet been …

Maternal postpartum corticosterone and fluoxetine differentially affect adult male and female offspring on anxiety-like behavior, stress reactivity, and hippocampal …

AR Gobinath, JL Workman, C Chow, SE Lieblich… - …, 2016 - Elsevier
Postpartum depression (PPD) affects approximately 15% of mothers, disrupts maternal care,
and can represent a form of early life adversity for the developing offspring. Intriguingly, male …

Delayed physical and neurobehavioral development and increased aggressive and depression-like behaviors in the rat offspring of dams fed a high-fat diet

CÁ Giriko, CA Andreoli, LV Mennitti… - International journal of …, 2013 - Elsevier
Early maternal exposure to a high-fat diet (HFD) may influence the brain development of rat
offspring and consequently affect physiology and behavior. Thus, in the present study, we …

Hippocampal HDAC4 contributes to postnatal fluoxetine-evoked depression-like behavior

A Sarkar, P Chachra, P Kennedy, CJ Pena… - …, 2014 - nature.com
Fluoxetine treatment in adulthood evokes antidepressant and anxiolytic responses.
Paradoxically, postnatal fluoxetine (PNFlx) induces persistent depression-and anxiety-like …

Genetic and pharmacological manipulations of the serotonergic system in early life: neurodevelopmental underpinnings of autism-related behavior

K Kinast, D Peeters, SM Kolk, D Schubert… - Frontiers in cellular …, 2013 - frontiersin.org
Serotonin, in its function as neurotransmitter, is well-known for its role in depression, autism
and other neuropsychiatric disorders, however, less known as a neurodevelopmental factor …

Long-term outcomes of developmental exposure to fluoxetine: a review of the animal literature

V Kiryanova, BB McAllister, RH Dyck - Developmental neuroscience, 2013 - karger.com
During and following pregnancy, women are at high risk of experiencing depression, for
which fluoxetine (FLX; brand names Prozac, Sarafem, Rapiflux) is the most commonly …

Long‐term consequences of neonatal fluoxetine exposure in adult rats

MC Ko, LJH Lee, Y Li, LJ Lee - Developmental Neurobiology, 2014 - Wiley Online Library
ABSTRACT Serotonin (5‐HT) plays important roles during neural development.
Administration of selective serotonin reuptake inhibitor (SSRI)‐type medication during …